动态参数的准确性用于预测流体响应在老年患者的感染性休克
Sittikorn Paphawin1, Pongdhep Theerawit2, Detajin Junhasavasdikul3
1Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
International journal of general medicine
|May 5, 2025
概括
脉压变化 (PPV) 和中风体积变化 (SVV) 准确预测老年败血症患者的液体反应. 动态动脉弹性 (Eadyn) 也可以预测平均动脉压响应.
科学领域:
- 关键护理医学 关键护理医学
- 心血管生理学心血管生理学
- 血液动力学监测 血液动力学监测
背景情况:
- 患有败血性休克的老年患者在血液动力学管理中存在独特的挑战.
- 精确预测流体反应能力对于优化性休克的结果至关重要.
- 像PPV,SVV和Eadyn这样的动态指数越来越多地用于指导流体治疗.
研究的目的:
- 评估脉冲压变化 (PPV),中风体积变化 (SVV) 和动态动脉弹性 (Eadyn) 在预测流体响应 (FR) 的准确性.
- 评估这些动态指数在患有败血性休克的老年患者中预测平均动脉压 (MAP) 反应的能力.
- 确定PPV,SV和Eadyn的最佳切割值,以预测该人群中的FR和MAP反应.
主要方法:
- 一项前性研究招募了65岁以上的感染性休克机械呼吸患者.
- 测量了PPV,SVV和Eadyn在液体加载之前和之后.
- 流体响应被定义为心脏输出增加≥10%;MAP响应被定义为MAP增加≥10%.
- 使用接收器操作特征 (ROC) 曲线分析来确定预测精度 (AUC) 和最佳切割值.
主要成果:
- 在流体反应者中,PPV和SVV显着更高 (p < 0.001),AUC分别为0.875和0.841.
- 最佳门是PPV13.5% (灵敏度81.8%,特异性87%) 和SVV11.5% (灵敏度81.8%,特异性87%).
- 在MAP响应者 (p = 0.013) 中,Eadyn较高,AUC为0.844和最佳值为1.00 (灵敏度85.7%,特异性75%).
结论:
- PPV和SVV是患有败血性休克的老年患者流体反应的可靠预测指标.
- 在这个患者群体中,Eadyn是MAP响应能力的有价值预测指标.
- 这些动态指数可以帮助指导老年败血症休克患者的流体管理策略.
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