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无标签全代谢光学成像使用in vivo隔热冷固定和冷微光切割断层扫描

Guoqing Fan^1,2,3, Mingyu Tian^1,2, Huijuan Pan^1,2

¹Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan 430074, China.

Biomedical optics express

|May 5, 2025

概括

新的冷成像方法可视化整个脏的代谢状态. 这种技术在2型糖尿病模型中揭示了代谢障碍,为器官研究提供了新的工具.

科学领域:

生物医学成像技术生物医学成像技术
代谢研究研究代谢研究
脏生理学脏生理学

背景情况:

低温成像为脏代谢状态的无标签可视化提供了潜力.
限制包括不均的代谢信息固定和不完整的3D器官形态.

研究的目的:

建立一个统一的冷固定和代谢映射的3D可视化管道.
以微米级分辨率评估整个脏的代谢状态.

主要方法:

开发了一种in vivo的绝缘冷固定技术.
集成的冷微光学切割断层扫描 (冷MOST) 用于3D可视化.
应用管道来研究db/db小鼠患有2型糖尿病.

主要成果:

实现组织的均和完整的冷固定.
启用了微米级分辨率的代谢映射的3D可视化.
在db/db小鼠中发现氧还原比增加,表明代谢障碍.

结论:

开发的管道提供了一个方便的光学成像工具,用于对整个脏代谢状态进行定量评估.
该方法提供了对代谢的微分辨率见解.
潜在的应用扩展到其他器官的代谢研究.

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