相关实验视频

Updated: May 9, 2025

Development of an Economical DNA Delivery System by "Acufection" and its Application to Skin Research

Development of an Economical DNA Delivery System by "Acufection" and its Application to Skin Research

Published on: April 19, 2017

探索青黄素对IMQ诱导的牛皮的治疗和肠道微生物群调节效果

Zhengyao Yu^1,2,3,4,5, Yingying Wang^2,3,6, Yingxue Guo^2,3,6

¹The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine), Hangzhou, Zhejiang, 310006, People's Republic of China.

Drug design, development and therapy

|May 5, 2025

概括

青兰素 (QRLXF) 通过调节T辅助17 (Th17) 细胞反应和改变肠道微生物群来治疗牛皮. 这种传统中医药在牛皮治疗方面表现有前途.

科学领域:

皮肤病学皮肤病学
免疫学免疫学免疫学
微生物学微生物学

背景情况:

牛皮是一种慢性炎症性皮肤疾病.
肠道微生物群失生症与牛皮病原发生有关.
传统中医 (TCM) 提供了潜在的治疗途径.

研究的目的:

为了研究青龙 (QRLXF) 对牛皮的治疗效果.
探索QRLXF对肠道微生物群调节的影响.
阐明QRLXF在牛皮的潜在分子机制.

主要方法:

网络药理学被用来识别关键化合物和标.
用小鼠牛皮病模型来评估QRLXF的疗效.
16S rRNA基因测序分析了肠道微生物群的组成.
流细胞计评估了T细胞亚群群体.

主要成果:

在小鼠中,QRLXF改善了牛皮皮炎和减少了炎症.
网络药理学表明Th17细胞分化调节是关键机制.
观察到肠道微生物群的显著变化,Ligilactobacillus和Lactobacillus的增加.
注意到Anaerotruncus,Negativibacillus,Bilophila和Mucispirillum的数量有所减少.

结论:

QRLXF证明了牛皮的治疗潜力.
治疗疗效与Th17细胞反应的调节有关.
QRLXF修改了肠道微生物群的形状,表明肠-皮肤轴的连接.

关键词:

16SrDNA测序的使用 QRLXFQRLXF QRLXFQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQ T细胞分化的特异化 Th17细胞的反应.牛皮是一种牛皮.

更多相关视频

Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model

Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model

Published on: April 6, 2022

Author Spotlight: Exploring ShiDuGao's Multi-Target Approach in Anus Eczema Treatment

Author Spotlight: Exploring ShiDuGao's Multi-Target Approach in Anus Eczema Treatment

Published on: January 12, 2024

相关概念视频

Inflammatory Bowel Disease IV: Pharmacological Management

Inflammatory Bowel Disease IV: Pharmacological Management

Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...