相关实验视频

Updated: Jun 23, 2026

Following in Real Time the Impact of Pneumococcal Virulence Factors in an Acute Mouse Pneumonia Model Using Bioluminescent Bacteria

Following in Real Time the Impact of Pneumococcal Virulence Factors in an Acute Mouse Pneumonia Model Using Bioluminescent Bacteria

Published on: February 23, 2014

在ICU中引起罕见NFGNB的细菌病:单中心体验

Parikshit S Prayag¹, Prasad Rajhans², Nilesh Mahale²

¹Department of Infectious Diseases, Deenanath Mangeshkar Hospital, Pune, Maharashtra, India.

Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine

|May 5, 2025

概括

印度ICU的罕见非发酵型阴性细菌 (NFGNB) 细菌病在印度ICU中经常发生在住院晚期,治疗选择有限,死亡率高. 严格的感染控制对于打击这种威胁至关重要.

科学领域:

医学微生物学医学微生物学
传染性疾病传染性疾病
密集护理医学密集护理医学

背景情况:

非发酵型阴性细菌 (NFGNB) 是医疗保健环境中的重要病原体.
虽然 Pseudomonas 和 Acinetobacter 是常见的,但更罕见的 NFGNB 正在成为感染的重要原因.
这项研究重点关注印度重症监护室 (ICU) 罕见NFGNB引起的细菌病的临床经验.

研究的目的:

描述印度ICU中罕见NFGNB引起的细菌病的流行病学和临床特征.
确定与这些患者死亡相关的风险因素.
评估这些罕见的NFGNB的体外抗生素敏感性模式.

主要方法:

一项回顾性研究对接受ICU治疗的成年患者进行,这些患者患有罕见NFGNB引起的细菌病.
收集的数据包括患者人口统计,临床特征,住院时间,致病生物和结果.
对各种抗菌剂进行了抗生素敏感性测试.

主要成果:

最常见的原因是Burkholderia物种 (43.4%),其次是Stenotrophomonas物种 (20.4%).
与导管相关的血流感染占42.9%的病例,在细菌病之前的住院时间中位数为16天.
梅罗因表现出高耐药性,而科特里莫克萨,莱沃素和米诺环素在体外通常是有效的. 第28天死亡率为34.1%.

结论:

在ICU中罕见的NFGNB细菌病与晚期获得,有限的治疗选择和显著的死亡率有关.
冲击和类固醇使用被确定为死亡率的独立预测因素.
加强感染控制措施对于减轻这些感染的影响至关重要.

关键词:

细菌病是什么意思细菌病是什么意思伯克霍尔德里亚斯的情况是这样的.格拉姆阴性细菌是一种细菌.非发酵剂的非发酵剂

更多相关视频

Isolation of Single Intracellular Bacterial Communities Generated from a Murine Model of Urinary Tract Infection for Downstream Single-cell Analysis

Isolation of Single Intracellular Bacterial Communities Generated from a Murine Model of Urinary Tract Infection for Downstream Single-cell Analysis

Published on: April 16, 2019

Neisseria meningitidis Infection of Induced Pluripotent Stem-Cell Derived Brain Endothelial Cells

Neisseria meningitidis Infection of Induced Pluripotent Stem-Cell Derived Brain Endothelial Cells

Published on: July 14, 2020

相关概念视频

Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic

Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic

Healthcare-associated infections (HAIs) occur in a healthcare facility while a person receives care for another ailment. This category also includes work-related infections among healthcare staff.
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies. Common...

Pneumonia I: Introduction

Pneumonia I: Introduction

Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...

Acute Pyelonephritis II: Diagnostic Studies and Management

Acute Pyelonephritis II: Diagnostic Studies and Management

Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...

Bacterial Meningitis

Bacterial Meningitis

Bacterial meningitis is a severe infectious disease involving inflammation of the meninges, the protective membranes surrounding the brain and spinal cord. It occurs when pathogenic bacteria cross the blood–brain barrier and enter the cerebrospinal fluid. Common causative organisms include Neisseria meningitidis, Streptococcus pneumoniae, Haemophilus influenzae type b, Listeria monocytogenes, and Escherichia coli K1. The exact route of entry varies by pathogen and host condition.Routes of Entry...

Bacterial Meningitis I: Introduction

Bacterial Meningitis I: Introduction

Bacterial meningitis is a severe, life-threatening inflammation of the meninges, particularly the pia mater and arachnoid mater, affecting the subarachnoid space, ventricles, and cerebrospinal fluid (CSF). If untreated, it can lead to significant neurological complications or death.Causative AgentsCommon pathogens vary with age and immune status. In adults, major organisms include Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Streptococcus agalactiae (group B...

Pneumonia I: Introduction

Pneumonia I: Introduction

Pneumonia is an infection of the lower respiratory tract that leads to inflammation of the lung parenchyma, often resulting in the accumulation of inflammatory exudate in the alveoli and airways. Unlike the watery, low-protein fluid exudate in pulmonary edema, the exudate in this case is a thick fluid rich in immune cells, proteins, and debris produced during infection and inflammation.This impairs gas exchange and can lead to consolidation of lung tissue. The infection may be caused by a...