后COVID-19时代儿童的严重帕尔沃病毒B19相关心肌炎:一个多中心观察队列研究
Neal Russell1, James Hatcher2,3, Tim Best2
1Department of Paediatric Infectious Diseases, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
Open forum infectious diseases
|May 5, 2025
概括
儿童严重的帕沃病毒B19感染越来越多地与心肌炎有关,导致重症监护室的入院. 早期对帕尔沃病毒B19的测试对于诊断严重的儿科心肌炎至关重要.
科学领域:
- 儿童心脏病学 儿童心脏病学
- 传染性疾病 传染性疾病
- 病毒学 病毒学
背景情况:
- 已经观察到循环帕尔沃病毒B19的增加.
- 帕尔沃病毒B19是众所周知的各种儿童疾病的原因.
研究的目的:
- 描述一组儿童中严重的帕尔沃病毒B19相关心肌炎病例.
- 为了突出帕尔沃病毒B19和严重的儿科心肌炎之间的关联.
主要方法:
- 在三个主要儿童中心进行了回顾性病例系列分析.
- 对临床数据的审查,包括重症监护室的入院和治疗方式.
- 实验室检测包括血清学和血液聚合酶链反应 (PCR) 检测帕尔沃病毒B19.
主要成果:
- 与前几年相比,在2024年观察到帕尔沃病毒B19相关心肌炎病例的显著增加.
- 大多数受影响的儿童 (93%) 需要重症监护.
- 很大一部分需要内 (88%) 和体外膜氧化 (15%).
结论:
- 帕尔沃病毒B19感染是严重的儿科心肌炎的重要原因.
- 肌心炎是帕尔沃病毒B19的晚期继发,通常需要密集护理.
- 对帕尔沃病毒B19的血清学和PCR测试应纳入重症儿科心肌炎的诊断工作.
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