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在实验性自身免疫性前列腺炎中,IGF1R促进Th17/Treg细胞的发展

Yu Guan¹, Shaoyu Yue¹, Yiding Chen¹

¹Department of Urology, The First Affiliated Hospital of Anhui Medical University; Institute of Urology & Anhui Province Key Laboratory of Urological and Andrological Diseases Research and Medical Transformation, Anhui Medical University, Hefei, Anhui, 230022, People's Republic of China.

Journal of inflammation research

|May 5, 2025

概括

胰岛素样生长因子1 (IGF1) 信号通过PKC-β促进Th17细胞分化,从而加剧慢性前列腺炎. 针对IGF1/IGF1R轴为这种情况提供了潜在的治疗策略.

科学领域:

泌尿器科泌尿器科泌尿器科泌尿器科
免疫学免疫学免疫学
内分泌学在内分泌学.

背景情况:

慢性前列腺炎是男性普遍存在的泌尿系统疾病,其特征是反复发作和不明原因.
胰岛素样生长因子1 (IGF1) 和其相关联体在慢性前列腺炎发病过程中的作用在很大程度上仍未被探索.

研究的目的:

研究IGF1/IGF1R轴在实验性自身免疫性前列腺炎 (EAP) 的发展和进展中的参与.
确定慢性前列腺炎治疗干预的潜在分子标.

主要方法:

建立了一种慢性自身免疫性前列腺炎 (EAP) 实验小鼠模型.
使用H&E染色,RT-qPCR,西斑,免疫光学和流细胞测量来分析前列腺组织和免疫细胞透.
使用腺相关病毒 (AAV) 进行基因淘汰和ELISA用于细胞因子测量.

主要成果:

在EAP小鼠的前列腺组织和CD4+ T细胞中,IGF1R的表达显著升高.
使用desIGF1的刺激加剧了前列腺炎症和疼痛,增加了Th17细胞和减少Treg细胞.
抑制IGF1R缓解了炎症和疼痛,使IGF1/IGF1R轴与疾病恶化有关.
PKC-β通路的激活与增加的Th17细胞分化和前列腺炎症有关.

结论:

IGF1/IGF1R轴,可能通过PKC-β信号传递,在EAP中的Th17细胞分化和前列腺炎症中起着至关重要的作用.
这个轴代表了一个有前途的分子标,用于开发慢性前列腺炎的新疗法策略.

关键词:

在IGF1R中,IGF1R是最重要的.在Th17/Treg细胞中.在前列腺炎前列腺炎.

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