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Updated: May 9, 2025

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在阿尔茨海默病小鼠中发现了一种小分子分泌的集群蛋白增强剂,可以改善阿尔茨海默病小鼠的记忆力

Whitaker Cohn1,2, Jesus Campagna1, Dongwook Wi1

  • 1The Drug Discovery Lab, Mary S. Easton Center for Alzheimer's Disease Research, Department of Neurology, David Geffen School of Medicine, 710 Westwood Plaza, University of California Los Angeles, Los Angeles, USA.

NPJ drug discovery
|May 5, 2025
PubMed
概括

这项研究确定了新的药物,可以提高分泌的集群蛋白 (sCLU) 水平,这是阿尔茨海默病 (AD) 风险的关键因素. 这些药物在减少AD病理和在小鼠模型中改善认知方面表现有前途.

关键词:
生物标志物 生物标志物药物查是指对药物进行查.药品化学 药品化学 是一个目标验证的目标验证.

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Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists

Cognitive enhancers, also known as "smart drugs," are substances used to enhance memory, mental alertness, and concentration. These can be natural or synthetic and improve cognition in conditions like Alzheimer's disease (AD) and other neurodegenerative diseases. Some common examples include caffeine, amphetamines, methylphenidate, modafinil, arecoline, donepezil, vortioxetine, and piracetam. These enhancers work on the principle of synaptic plasticity and altered circuit function.
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