COVID-19和上胃肠道出血;病因,危险因素和结果:一个病例对照研究
Sara Shafieipour1, Mohammad Rezaei Zadeh Rukerd2, Niloofar Farsiu1
1Gastroenterology and Hepatology Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran.
患有上部胃肠道出血 (UGIB) 的COVID-19患者面临更长的重症监护室 (ICU) 停留时间和更高的死亡率. 肝硬化病史和之前的胃肠道出血 (GIB) 是这些患者UGIB的重要风险因素.
科学领域:
- 胃肠病学 胃肠病学
- 传染性疾病 传染性疾病
- 关键护理医学 关键护理医学
背景情况:
- 胃肠道 (GI) 症状在COVID-19中很常见,但上胃肠道出血 (UGIB) 是一个关键的并发症.
- 了解UGIB在COVID-19患者中的特定风险和结果对于临床管理至关重要.
研究的目的:
- 为了调查病因,危险因素,食管胃管腺镜 (EGD) 发现,以及住院COVID-19患者的UGIB的结果.
- 在COVID-19感染的背景下确定UGIB的预测因子.
主要方法:
- 追溯病例控制研究涉及127名COVID-19患者.
- 通过逆转录聚合酶链反应 (RT-PCR) 诊断患者.
- 64名患有UGIB (病例) 和63名没有UGIB (对照) 的患者的比较.
主要成果:
- 梅伦娜 (37.5%) 和胃潰瘍 (21.87%) 分别是最常见的UGIB症状和EGD发现.
- 患有UGIB的COVID-19患者在ICU停留时间显著长 (11.58天与8.29天,P=0.03).
- 曾经患有GIB (17.2%) 和肝硬化 (12.5%) 是UGIB的显著风险因素 (分别P=0.001和P=0.01).
结论:
- 患有UGIB的COVID-19患者经历了更多的重症监护室 (ICU) 停留.
- 梅拉和胃是UGIB的COVID-19患者的常见表现和发现.
- 肝硬化和之前的GIB病史增加了COVID-19患者UGIB的风险.
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