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影像成像中的一个盲点:免疫检查点抑制剂诱导的心肌炎与阴性心脏MRI

Lubna Alnatour¹, Ayham Mahmoud², Ameer Awashra³

¹School of Medicine, University of Jordan, Amman, Jordan.

Methodist DeBakey cardiovascular journal

|May 5, 2025

概括

免疫检查点抑制剂 (ICI) 诱导的心肌炎是一种罕见但严重的疾病. 心脏MRI是诊断的关键,但如果成像不确切,可能需要活检.

科学领域:

心脏病学心脏病学
免疫学免疫学免疫学
在瘤学瘤学.

背景情况:

免疫检查点抑制剂 (ICI) 是革命性的癌症疗法.
心肌炎是ICI的罕见但严重的不良影响.
高发病率和死亡率与ICI诱导的心肌炎有关.

研究的目的:

突出ICI诱导心肌炎的诊断挑战.
强调心脏成像和活检在诊断中的作用.

主要方法:

关于ICI诱导心肌炎的当前文献的综述.
诊断途径的分析,包括心脏磁共振成像 (CMR) 和内心肌活检.

主要成果:

心脏磁共振成像 (CMR) 是主要的非侵入性诊断工具.
在CMR结果为负的病例中,心内膜活检对于诊断至关重要.

结论:

早期识别和准确诊断ICI诱导的心肌炎至关重要.
结合CMR和活检的多式诊断方法可确保及时管理.

关键词:

在CMR中,CMR是CMR.心脏瘤学心脏瘤学免疫检查点抑制剂 (ICI) 诱导的心肌炎.肌性心肌炎是一种心肌炎.

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