心血管磁共振成像老化标志物:一个多中心,横截面队列研究
Hosamadin S Assadi1,2, Xiaodan Zhao3, Gareth Matthews1,2
1Department of Cardiovascular and Metabolic Health, Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich NR4 7UQ, Norfolk, UK.
European heart journal open
|May 5, 2025
概括
心脏磁共振 (CMR) 可以预测功能性心脏年龄,揭示患有高血压和糖尿病等并发症的个体心脏年龄更高. 这个工具有助于评估心脏衰老和相关的心血管变化.
科学领域:
- 心脏病学 心脏病学
- 医疗成像医学成像
- 老年学是一门学科.
背景情况:
- 心脏衰老涉及影响心脏表现的结构和生理变化.
- 心脏磁共振 (CMR) 是评估与年龄有关的心血管重塑的关键成像方式.
- 量化功能性心脏年龄有助于理解心血管健康轨迹.
研究的目的:
- 开发和验证一个完全自动化的CMR模型来预测功能性心脏年龄.
- 在健康个体和具有心血管风险因素的队列中评估模型的准确性.
- 调查CMR衍生的心脏年龄和常见的并发症之间的关系.
主要方法:
- 使用国际,多中心数据的回顾性观察研究.
- 使用左心房 (LA) 末缩体积和LA喷射率开发自动化CMR模型.
- 在191名健康个体和366名患有并发症 (高血压,糖尿病,心房动,肥胖) 的患者队列中进行验证.
主要成果:
- 在健康个体中,CMR衍生的心脏年龄与时间年龄非常接近.
- 在验证队列中,功能性心脏年龄比时间年龄高4.6年.
- 在患有高血压,糖尿病和心房动的患者中观察到显著更高的CMR衍生的心脏年龄,肥胖的趋势.
结论:
- 这项研究提供了关于衰老过程中心脏结构和功能的时间变化的见解.
- 提出的基于CMR的方程可以帮助沟通与年龄有关的心脏评估变化.
- 自动化CMR分析为评估心血管健康和衰老提供了有价值的工具.
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