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PND1186的自乳化纳米PND口服输送系统:用于估计生物利用性的模拟

Mukti Vats¹, Drishti Rathod¹, Henis Patel¹

¹College of Pharmacy and Health Sciences, St. John's University, NY, USA.

Journal of molecular liquids

|May 5, 2025

概括

一种新型的自我纳米乳化药物递送系统,NanoPODS-S,增强了用于胰腺癌治疗的FAK抑制剂PND1186的口服生物可用性和细胞毒性.

科学领域:

药理学药理学是指药理学的学科.
纳米技术纳米技术
在瘤学瘤学.

背景情况:

焦粘附激酶 (FAK) 抑制剂在癌症治疗中显示出有前途的治疗作用.
一种FAK抑制剂PND1186 (PND) 面临着由于快速沉而导致口服生物利用性较差的情况.
这限制了其治疗胰腺管腺癌 (PDAC) 等癌症的潜力.

研究的目的:

开发和评估一种自纳米乳化口服输送系统 (NanoPODS) 用于PND.
提高PND的溶解性,生物可用性和抗癌功效,特别是对于PDAC.
引入纳米PODS-S,结合聚合物沉抑制剂,增强药物释放.

主要方法:

开发用于PND的自纳米乳化系统 (纳米PODS和纳米PODS-S).
纳米PODS-S的特性:颗粒大小,PDI,表面潜力和药物释放在pH 6.8.8时.
在体内药理动力学预测口服生物可用性.
对NanoPODS和NanoPODS-S在PDAC细胞系上的有效性进行评估.

主要成果:

优化的NanoPODS-S显示颗粒大小为107.0 ± 3.6nm,PDI为0.223 ± 0.016.
在pH 6.8下,NanoPODS-S实现了>70%的PND释放,并预测了99%的口服生物利用率.
该系统显示了针对PDAC细胞系的细胞毒性改善的潜力.

结论:

纳米PODS-S代表了一种新的自我纳米乳化系统,具有独特的"弹降落效应",用于增强溶解.
这种平台技术显著提高了口服生物可用性和抗癌疗效,像PND.这样的溶性较差的药物.
在癌症治疗中,NanoPODS-S有望有效地通过口服输送FAK抑制剂.

关键词:

在模型建模.口服生物可用性口服生物可用性韩国人民币 118686 美元胰腺腺癌 (Adenocarcinoma) 是一种胰腺癌.自体乳化系统自体乳化系统这就是Soluplus.

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