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Epigenetic Regulation

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...

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Updated: May 9, 2025

A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes

A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes

Published on: May 22, 2018

华盛顿大学表观基因组浏览器更新2025年

Chanrung Seng¹, Shane Liu¹, Wenjin Zhang¹

¹Department of Genetics, The Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63110, United States.

Nucleic acids research

|May 5, 2025

概括

华盛顿大学的表观基因组浏览器已被改写为更小,更快的代码库,提高了对探索基因组和表观基因组数据的性能和用户体验. 新功能包括用于甲基化数据的高级可视化和比较基因组学功能的功能.

更多相关视频

Enhanced Reduced Representation Bisulfite Sequencing for Assessment of DNA Methylation at Base Pair Resolution

Enhanced Reduced Representation Bisulfite Sequencing for Assessment of DNA Methylation at Base Pair Resolution

Published on: February 24, 2015

Pattern-based Search of Epigenomic Data Using GeNemo

Pattern-based Search of Epigenomic Data Using GeNemo

Published on: October 8, 2017

相关实验视频

Last Updated: May 9, 2025

A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes

A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes

Published on: May 22, 2018

Enhanced Reduced Representation Bisulfite Sequencing for Assessment of DNA Methylation at Base Pair Resolution

Enhanced Reduced Representation Bisulfite Sequencing for Assessment of DNA Methylation at Base Pair Resolution

Published on: February 24, 2015

Pattern-based Search of Epigenomic Data Using GeNemo

Pattern-based Search of Epigenomic Data Using GeNemo

Published on: October 8, 2017

科学领域:

基因组学就是基因组学.
生物信息学是一种生物信息学.
计算生物学计算生物学

背景情况:

华盛顿大学表观基因组浏览器是可视化和分析表观基因组数据的关键工具.
之前的版本面临着不断发展的JavaScript生态系统和外部库依赖性的挑战.
需要进行改进,以提高性能,用户体验和可维护性.

研究的目的:

将华盛顿大学表观基因组浏览器的显著更新版本与重写的代码库呈现出来.
为了提高浏览器的性能,加载效率和安装方便.
为高级数据可视化和比较基因组学引入新功能.

主要方法:

完全重写代码库,最小化外部JavaScript库.
为更小的代码捆绑大小优化生产编译.
实施一个模块化设计,以作为独立模块的潜在出口.
开发新的轨道类型,用于长读和单细胞甲基化数据可视化.
创建一个比较基因组学轨道来比较不同的基因组组 (例如,hg38和chm13).

主要成果:

实现了显著更小的代码捆绑大小,提高了加载效率和整体性能.
增强了脚本,图形染和绘画性能.
由于较少的外部依赖,使得安装速度更快,更简单.
为甲基化数据和比较基因组学引入了新的可视化轨道.
建立了一个数据中心,用于比较hg38和chm13基因组组合.

结论:

重新编写的WashU Epigenome浏览器提供了卓越的性能和用户体验.
模块化设计和减少的依赖性使维护和集成更容易.
新功能增强了复杂的表观基因组和基因组数据集的分析,包括比较基因组学.