在诊断非小细胞肺癌之前和之后,白内障的发病率和发展
L Anne Gilmore1, Jonas Willmann2, Santiago Olaechea1
1University of Texas Southwestern Medical Center, Dallas.
American journal of clinical oncology
|May 5, 2025
概括
卡切西亚是一种减肥的情况,在非小细胞肺癌 (NSCLC) 诊断前多达一年可以开始. 超过一半的NSCLC患者在诊断后的一年内患上白血病,这凸显了早期干预的必要性.
科学领域:
- 在瘤学瘤学.
- 代谢障碍 代谢障碍 代谢障碍
- 营养科学 营养科学
背景情况:
- 在癌症诊断时,常常会定义白内障,但早期体重变化对于理解癌症的发展至关重要.
- 诊断前的回顾性体重数据有限,导致潜在的回忆偏差.
研究的目的:
- 分析身体体重轨迹在非小细胞肺癌 (NSCLC) 诊断之前和之后的一年.
- 为了确定是否可以在诊断点之前更早地检测到缓冲症.
- 评估NSCLC患者诊断后的缓解症的患病率和进展情况.
主要方法:
- 对NSCLC患者诊断前和诊断后体重数据的电子健康记录的回顾性分析.
- 根据国际共识标准定义的白内障 (>5%或>2%的体重减轻根据BMI).
- 在3个月间隔分析体重数据,以追踪随时间的变化.
主要成果:
- 28%的NSCLC患者在诊断时表现出白血病,前一年平均体重减轻8.6%.
- 诊断后的体重减轻在患有或没有预诊断的患者中是相似的.
- 在诊断后的12个月内,58%的患者达到缓解症标准,体重减轻的时间平均为220天.
结论:
- 标志着缓解症的体重减轻可以早在NSCLC诊断前12个月就开始.
- 超过一半的NSCLC患者在诊断后的一年内患上白血病,特别是那些患有晚期疾病的人.
- 建议对NSCLC患者进行早期的营养和药理干预,以控制缓解症.
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