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在单侧声麻 (VOCALIST):一个随机的可行性研究中,喉再内接与I型甲状腺整形术相比

Martin Birchall¹, Eleftheria Iliadou^1,2, Helen Blackshaw¹

¹Ear Institute, University College London, London, UK.

The Laryngoscope

|May 5, 2025

概括

英国的一项可行性研究证实,可以进行第三阶段试验,比较喉再内线和I型胸膜整形术,以治疗单边声麻. 招募,随机化和结果测量对于最终的试验是可行的.

科学领域:

耳鼻喉科耳鼻喉科耳鼻喉科
神经外科神经外科
语音和语言治疗治疗

背景情况:

单侧声麻 (UVFP) 显著影响声音,吞和生活质量.
目前的治疗方案包括喉再生和I型甲状腺整形术.
需要在英国进行一项最终的随机对照试验 (RCT) 来比较这些干预措施.

研究的目的:

评估在英国进行多中心III期RCT的可行性.
为了比较喉再内接与成人UVFP的I型胸膜整形.
为了评估招聘率,随机化的可接受性和学率.

主要方法:

一项可行性研究,涉及英国三个地点的27名参与者.
试验程序反映了一个全面的RCT.
包括一个并行的定性研究来探索招聘.
最长12个月的后续对结果措施的评估.

主要成果:

成功招募了23名患者 (12名重新内核化,11名胸部整形).
高参与者接受 (96%) 的分配治疗.
识别了可通过培训解决的轻微招聘挑战.
结果测量显示了对干预措施的响应性.

结论:

对UVFP进行最终的英国RCT,比较再内尔化和胸膜整形是可行的.
在试验进行,招募,结果测量和完成方面确认可行性.
这项研究为更大,充足动力的试验提供了保证.

关键词:

失声症 (dysphonia) 是一种听觉障碍.重新内化是指重新内化甲状腺整形术 (Tyroplasty) 是一种治疗术.一个声音,一个声音,一个声音.

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