格林的表达可以调节二度心脏功能在2型糖尿病肥胖患者?
Celestino Sardu1, Nunzia D'Onofrio2, Maria Consiglia Trotta2
1Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", Naples, Italy.
Diabetes/metabolism research and reviews
|May 5, 2025
概括
在患有2型糖尿病 (T2DM) 肥胖患者的腹部脂肪切除减少了炎症,改善了左心室扩张功能 (LV-DF). 这种干预增加了血清胆固醇和与LV-DF正常化相关的特定微RNA (miRs).
科学领域:
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
- 代谢综合征是代谢综合征的一种.
背景情况:
- 脂肪组织的细胞因子,Sirtuin-1 (SIRT1) 和微RNAs (miRs) 影响左心室的扩张功能 (LV-DF).
- 格林可以调节2型糖尿病 (T2DM) 肥胖患者的这些途径.
研究的目的:
- 研究T2DM肥胖患者在腹部脂肪切除后的格林表达.
- 评估腹部脂肪切除对LV-DF正常化的一年随访后的影响.
主要方法:
- 经过腹部整形手术的222名T2DM肥胖患者根据LV-DF严重程度进行了分类.
- 分析了组织和血清标记物,包括炎症性细胞因子,SIRT1,-葡萄糖输送二 (SGLT2), ghrelin 和 miRs (miR-21, miR-92, miR-126).
主要成果:
- 患有LV-透支功能障碍的患者表现出较高的炎症,SGLT2和改变的miR表达,SIRT1.1较低.
- 腹部脂肪切除导致炎症和SGLT2减少,血清胆固醇增加,以及有利的miR表达变化.
- 随访时LV-DF正常化是由组织miR-126和血清胆固醇水平预测的.
结论:
- 在T2DM肥胖患者的腹部脂肪切除可以降低炎症并调节SIRT1,SGLT2,ghrelin和miRs.
- 这些变化有助于左心室扩张功能在手术后一年正常化.
- 格林和特定的miRs在预测脂肪减肥手术后LV-DF恢复方面发挥着作用.
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