47年来追踪形腺瘤发病率趋势:一个基于人口的研究
Katelyn S Rourk1, Ghazal S Daher2, Jenna R Schwartz1
1Mayo Clinic Alix School of Medicine, Mayo Clinic, Rochester, Minnesota, USA.
概括
奥尔姆斯特德县的多形腺瘤 (PA) 发病率在过去五十年中有所增加,诊断转向偶然发现和年龄较大. 治疗趋势显示,较少的广泛手术的增加.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 头部和部手术 头部和部手术
- 流行病学 流行病学
背景情况:
- 多形腺瘤 (PAs) 是最常见的良性唾液腺瘤.
- 了解PA发生率和临床表现的长期趋势对于资源配置和患者管理至关重要.
研究的目的:
- 在明尼苏达州奥尔姆斯特德县,在五十年内追踪形腺瘤 (PAs) 的发病率.
- 为了比较这一时期与PA相关的人口和治疗趋势.
主要方法:
- 从1976年到2022年,对1976年至2022年病理诊断的非复发性形腺瘤患者进行了回顾性队列研究.
- 发病率按每10万人/年,年龄和性别计算,根据美国2020年人口普查数据进行调整.
- 统计分析包括波桑率回归,斯皮尔曼等级相关性,威尔科克森等级和和克鲁斯卡尔-瓦利斯测试.
主要成果:
- 总共有251名PA患者被确定,平均年龄为50.0岁,女性略有占主导地位.
- 调整后的发病率从2.50/100,000人/年 (1976-1979) 增加到5.73/100,000人/年 (2020-2022).
- 不那么广泛的手术增加了,而全腹膜切除术减少了;偶然的成像发现和诊断时的年龄也增加了.
结论:
- 奥尔姆斯特德县形腺瘤的发病率高于此前报告的美国估计,并且已显著增加.
- 转变的趋势包括偶然诊断的比例更高,诊断时的年龄增加,以及向更少侵入性的外科手术方法的转变.
- 这些变化反映了成像技术的进步和老龄化人口寻求治疗良性状体质的治疗.
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