身体质量指数升高加剧了鼻的组织病理变化和术后复发风险
Sijie Jiang1,2,3,4, Liyuan Liu5, Hua Zhang1,2,3,4
1Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital of Central South University, Changsha, Hunan, People's Republic of China.
概括
患有鼻息息肉 (CRSwNP) 慢性鼻炎的患者体质指数 (BMI) 升高与更高的复发率和特定组织变化有关. 超重和肥胖会加剧炎症,增加CRSwNP在手术后复发的风险.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 免疫学 免疫学 免疫学
- 病理学 病理学 病理学
背景情况:
- 带鼻息肉的慢性鼻炎 (CRSwNP) 是一种复杂的炎症状况.
- 了解影响复发的因素对于有效管理至关重要.
研究的目的:
- 调查身体质量指数 (BMI) 和组织病理特征之间的关联.
- 确定BMI对CRSwNP术后复发风险的影响.
主要方法:
- 对577名CRSwNP患者进行了回顾性临床研究.
- 根据BMI,患者被分为正常体重,超重和肥胖群体.
- 对组织病理特征和3年术后复发率的分析.
主要成果:
- 超重和肥胖的CRSwNP患者出现了更高的复发率,组织中氨基酸细胞数量和IL-5/IL-17A水平.
- 超重/肥胖群体中经常出现的病例中,有过高的乙氨基和IL-5/IL-17A.
- 肥胖与氨基酸透和炎症标志物增加有关,特别是在修复手术期间.
结论:
- 升高的BMI显著影响CRSwNP的组织病理变化.
- 超重和肥胖会加剧组织中乙氨基酸透和IL-5/IL-17A的表达.
- 这些因素有助于CRSwNP的复发机制,突出显示BMI是危险因素.
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