阴道微生物组对女性不孕症和辅助怀孕结果的影响
Xiuju Chen1, Yanyu Sui1, Jiayi Gu1
1Department of Reproductive Medicine, Second Affiliated Hospital of Naval Medical University, Shanghai 200003, China.
Genomics, proteomics & bioinformatics
|May 5, 2025
概括
阴道微生物群在生育和不育妇女之间有显著差异,特定的细菌与不育和复发性植入失败 (RIF) 有关. 了解这些微生物差异可能会提高辅助生殖技术 (ART) 的成功.
科学领域:
- 生殖生物学 生殖生物学
- 微生物组研究 微生物组研究
- 基因组学就是基因组学.
背景情况:
- 不孕率的上升需要了解影响女性生育能力的因素.
- 人们越来越认识到阴道微生物群在生殖健康和辅助生殖技术 (ART) 成功中的作用.
研究的目的:
- 为了比较受孕和不孕妇女的阴道微生物组合.
- 研究阴道微生物群对ART结果的影响,特别是在复发性植入失败 (RIF) 的情况下.
主要方法:
- 用16S rRNA基因测序对194名不育妇女和100名对照妇女的阴道分泌物进行分析.
- 机器学习的应用用于不孕症预测和PICRUSt用于代谢途径分析.
主要成果:
- 与对照组相比,不孕妇女表现出明显的阴道微生物组成,其多样性更高.
- 在不孕妇女中观察到高水平的Burkholderia,Pseudomonas和Prevotella,与减少的Bifidobacterium和Lactobacillus.
- 复发性植入失败 (RIF) 病例显示出更大的微生物多样性,Mobiluncus,Peptoniphilus,Prevotella和Varibaculum的丰富性增加.
结论:
- 在受孕和不孕妇女之间存在阴道微生物群的显著差异.
- 特定的微生物种群和代谢途径与不孕症和RIF有关,为干预提供了潜在的目标.
- 了解阴道微生物群的影响对于提高ART成功率至关重要.
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