阿坎萨摩巴角膜炎的自然史:一个系统的文献综述
Vincenzo Papa1, Danielle H Bodicoat2, Angela Arteaga Duarte2
1SIFI S.P.A., 36, Via Ercole Patti, 95025, Aci S. Antonio, Catania, Italy. Vincenzo.Papa@sifigroup.com.
Ophthalmology and therapy
|May 5, 2025
概括
在有效的抗阿米治疗之前,阿坎萨摩巴角膜炎 (AK) 的结局不佳. 大多数患者需要治疗性角质塑造 (TK) 或核切除,很少有人在没有手术的情况下获得医学治愈.
科学领域:
- 眼科医生 眼科 眼科
- 传染性疾病 传染性疾病
- 微生物学 微生物学
背景情况:
- 阿坎萨摩巴角膜炎 (AK) 是一种严重的眼部感染.
- 早期的AK治疗是无效的,导致不良结果和频繁的手术干预.
- 了解历史治疗结果为当前疗法提供了基准.
研究的目的:
- 在有效的抗菌药物可用之前,评估Acanthamoeba角膜炎的治疗结果.
- 在治疗选择有限的时期描述AK的自然史.
- 为了建立一个历史基准来比较当前的AK治疗疗效.
主要方法:
- 系统的文献审查,遵循PRISMA指南,对1970年至1995年间发表的研究进行审查.
- 纳入标准:没有确定的抗阿梅比克药物 (比瓜尼德或迪米丁) 治疗的AK患者.
- 评估结果:医疗疗愈合,治疗性角膜整形 (TK) 和核化,以比例和置信区间估计.
主要成果:
- 分析了56份病例报告,使用隐形眼镜 (68.2%) 和创伤 (31.8%) 是主要的风险因素.
- 平均诊断延迟7.3周;只有23.2%的人在4周内被诊断出来.
- 医疗治愈率为19.6%,而67.9%需要TK和5.4%进行了核化.
结论:
- 在像普罗帕米丁这样的有效治疗方法出现之前,阿坎萨摩巴角膜炎的预后很差.
- 手术干预,特别是治疗性角质整形,是主要的结果.
- 这些发现突显了早期抗阿梅比克疗法对AK患者结果的重大影响.
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