相关实验视频

Updated: May 9, 2025

Nuclei Isolation from Fresh Frozen Brain Tumors for Single-Nucleus RNA-seq and ATAC-seq

Nuclei Isolation from Fresh Frozen Brain Tumors for Single-Nucleus RNA-seq and ATAC-seq

Published on: August 25, 2020

癌症单细胞测序的全球和当前研究趋势:一个图书识别和可视化研究

Xiuyun Song¹, Heyuan Niu², Kaiyu Li²

¹Department of Operating Theatre, Tianjin Medical University General Hospital.

Journal of visualized experiments : JoVE

|May 5, 2025

概括

图书统计分析显示,癌症研究中单细胞测序的快速进展. 关键趋势包括瘤内部异质性和免疫疗法,由全球合作和技术创新驱动.

科学领域:

瘤学和基因组学在
生物技术和生物信息学

背景情况:

癌症的复杂性需要先进的分析工具来理解生物系统.
单细胞测序 (SCS) 提供了在单个细胞水平上对基因表达和表观遗传学的高分辨率洞察力.

研究的目的:

在癌症中进行单细胞测序研究的文献分析.
阐明2010年至2023年的研究趋势,协作网络和知识传播.

主要方法:

使用Web of Science核心集合 (2010-2023) 的图书统计分析.
使用R的Bibliometrix软件包进行数据提取和分析.
使用CiteSpace,VOSviewer和文学计量学的在线分析平台进行可视化.

主要成果:

确定了5,680个出版物,涉及来自75个国家的3,129个机构的34,074名作者.
中国和美国在出版量方面处于领先地位;哈佛大学是最多产的机构.
关键的研究领域包括免疫微环境,免疫疗法,瘤内异质性和克隆进化.

结论:

由于技术进步和国际合作,瘤学中的单细胞测序正在迅速发展.
未来的研究应该集中在瘤内异质性,克隆进化和药物输送系统上.
加强全球伙伴关系和分析工具对于个性化癌症疗法至关重要.

更多相关视频

Author Spotlight: Exploring Strategies for Successful Immune Response Against Tumors

Author Spotlight: Exploring Strategies for Successful Immune Response Against Tumors

Published on: August 16, 2024

An Ultrahigh-throughput Microfluidic Platform for Single-cell Genome Sequencing

An Ultrahigh-throughput Microfluidic Platform for Single-cell Genome Sequencing

Published on: May 23, 2018

相关概念视频

Next-generation Sequencing

Next-generation Sequencing

The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features....