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Updated: Jul 26, 2026

Long-term Silencing of Intersectin-1s in Mouse Lungs by Repeated Delivery of a Specific siRNA via Cationic Liposomes. Evaluation of Knockdown Effects by Electron Microscopy
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针对使用改性乙醇注射方法为瘤治疗而制备的基于cationic triacyl lipid的siRNA lipoplex,优化PEGylation

Yoshiyuki Hattori1, Mizuki Shinkawa1, Aya Kurihara1

  • 1Department of Molecular Pharmaceutics, Hoshi University, Shinagawa, Tokyo, Japan.

Journal of liposome research
|May 5, 2025
PubMed
概括

改性乙醇注射 (MEI) 方法构建小干扰RNA (siRNA) 脂质复合体. 使用10%的PEG胆固醇乙烯 (PEG-Chol) 进行PEG化,维持了治疗效果并减少了肺部积累,提供了一个有前途的癌症治疗输送系统.

关键词:
脂质复杂症 (Lipoplex) 是一种通过PEGylation进行化.这种基因被淘汰了.波罗样类激酶1 (Polo-like kinase1) 是一种类似波罗的激酶.siRNA的传递方式瘤治疗的治疗方法

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