一般人群中PWV与GLS的比率:非侵入性心室动脉指数的参考值,相关值和预测值
Nicholas Cauwenberghs1, Hannah Vanwinkel1, Evangelos Ntalianis1
1Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Leuven, Belgium.
Echocardiography (Mount Kisco, N.Y.)
|May 5, 2025
概括
带 - 骨脉冲波速率 (cfPWV) 与左心室全球纵向应变 (GLS) 的比率具有特定于年龄和性别的参考值. 虽然较高的cfPWV/GLS预测了心血管事件,但它不是一般人群中的独立预测因素.
科学领域:
- 心血管成像和诊断服务
- 在心脏病学中发现生物标志物
- 血管和心脏机械学
背景情况:
- 整合心室和动脉功能的非侵入性成像标记物对于预测心脏病至关重要.
- 带 - 骨脉冲波速率 (cfPWV) 与左心室全球纵向应变 (GLS) 的比率是一个新的潜在标志物.
研究的目的:
- 在一般人群中确定cfPWV/GLS比率的参考值.
- 为了确定cfPWV/GLS比率的临床相关性.
- 评估cfPWV/GLS比率对发生心血管事件的预测值.
主要方法:
- 用平面度测量测量的关节-关节脉冲波速率 (cfPWV).
- 左心室全球纵向应变 (GLS) 通过心声学评估在1026个个体.
- 来自低风险子样本的参考值;通过逐步回归确定的临床相关值;为心血管事件计算的多变量调整的危险比率.
主要成果:
- 对于cfPWV/GLS,特定于年龄和性别的正常的上限从0.41 m/s% (年轻女性) 到0.64 m/s% (年长男性) 之间.
- 较高的cfPWV/GLS与男性性别,年龄,心率,脉冲压,平均动脉压和左心室质量相关.
- 虽然GLS单独预测了CV事件,并且cfPWV/GLS比率高于预测事件的中位数,但异常cfPWV/GLS在通过参考限值或文献切断界限定义时并没有独立预测事件.
结论:
- 确定了cfPWV/GLS的特定年龄和性别的参考值.
- cfPWV/GLS比率与年龄,性别和血压参数有关.
- 与单独的GLS不同,cfPWV/GLS比率并没有成为社区心血管事件的独立预测指标.
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