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Updated: Jun 9, 2026

Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms
11:36

Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms

Published on: May 29, 2020

探索已知或假设的T细胞介导药物诱导肝损伤的精确描述的机制模型:当前能力和未来预测能力的挑战

Lara Clemens1, Christina Battista1, Zackary R Kenz1

  • 1QSP Solutions, Simulations Plus, Inc., Research Triangle Park, NC, USA.

Expert opinion on drug metabolism & toxicology
|May 5, 2025
PubMed
概括

量化系统毒理学建模现在包括CD8+ T细胞介导的药物诱导性肝损伤 (DILI). 这种方法成功地在小鼠和人类模型中复制了DILI数据,为减少药物开发中的DILI提供了有希望的方向.

关键词:
氨酸氨基转移酶 (ALT) 的使用CD8+ T 细胞 CD8+ T 细胞DILIsym 的意思是药物引起的肝损伤 (DILI)量化系统毒理学 (QST) 的研究.

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Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro11:06

Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro

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Mechanistic models, a category encompassing both physiological and compartmental modeling, differ from empirical models' approaches to incorporating known factors about the systems being modeled. Empirical models describe data with minimal assumptions, while mechanistic models aim to provide a robust description of available data by specifying assumptions and integrating known factors about the system. Compartmental analysis is a key example of a mechanistic model in pharmacokinetics and...
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