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相关概念视频

Functions of Thyroid Hormones01:18

Functions of Thyroid Hormones

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The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
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Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

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Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
3.9K
The Thyroid Gland01:23

The Thyroid Gland

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The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
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相关实验视频

Updated: May 9, 2025

Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model
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根据年龄,性别和种族的甲状腺功能参考间隔:一个横截面研究.

Qihang Li1, Yida Tang2, Xuefeng Yu3

  • 1Department of Endocrinology, Shandong Provincial Hospital, Shandong University; Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education; Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University; Shandong Clinical Research Center of Diabetes and Metabolic Diseases; and Shandong Institute of Endocrine and Metabolic Diseases, Jinan, Shandong, China (Q.L., J.Z.).

Annals of internal medicine
|May 5, 2025
PubMed
概括

根据年龄,性别和种族开发特定的甲状腺功能参考间隔显著改变了疾病的分类. 这些量身定制的间隔重新分类了许多个体,提高了甲状腺疾病的诊断准确度.

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科学领域:

  • 内分泌学 在内分泌学.
  • 临床化学 临床化学
  • 公共卫生 公共卫生

背景情况:

  • 目前的甲状腺功能测试使用了通用参考间隔.
  • 这种方法忽略了年龄,性别和种族的关键人口统计差异.

研究的目的:

  • 为了确定甲状腺功能测试的年龄,性别和种族特定的参考间隔.
  • 为了比较疾病重新分类使用新的间隔与当前标准.

主要方法:

  • 美国NHANES和中国健康检查数据的横截面分析.
  • 定义的参考间隔使用2.5至97.5百分位数为子组.

主要成果:

  • 甲状腺刺激激素 (TSH) 随着年龄的增长而增加;TT3下降;TT4稳定.
  • 女性TT4较高;白人参与者TSH较高.
  • 新的间隔重新分类了48.5%的亚临床甲状腺功能低下症和31.2%的亚临床甲状腺功能过高症病例.

结论:

  • 年龄,性别和种族特定的参考间隔对于准确的甲状腺疾病诊断至关重要.
  • 这些发现支持在定义和管理甲状腺疾病方面形成共识.