根据年龄,性别和种族的甲状腺功能参考间隔:一个横截面研究
Qihang Li1, Yida Tang2, Xuefeng Yu3
1Department of Endocrinology, Shandong Provincial Hospital, Shandong University; Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education; Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University; Shandong Clinical Research Center of Diabetes and Metabolic Diseases; and Shandong Institute of Endocrine and Metabolic Diseases, Jinan, Shandong, China (Q.L., J.Z.).
Annals of internal medicine
|May 5, 2025
概括
根据年龄,性别和种族开发特定的甲状腺功能参考间隔显著改变了疾病的分类. 这些量身定制的间隔重新分类了许多个体,提高了甲状腺疾病的诊断准确度.
科学领域:
- 内分泌学 在内分泌学.
- 临床化学 临床化学
- 公共卫生 公共卫生
背景情况:
- 目前的甲状腺功能测试使用了通用参考间隔.
- 这种方法忽略了年龄,性别和种族的关键人口统计差异.
研究的目的:
- 为了确定甲状腺功能测试的年龄,性别和种族特定的参考间隔.
- 为了比较疾病重新分类使用新的间隔与当前标准.
主要方法:
- 美国NHANES和中国健康检查数据的横截面分析.
- 定义的参考间隔使用2.5至97.5百分位数为子组.
主要成果:
- 甲状腺刺激激素 (TSH) 随着年龄的增长而增加;TT3下降;TT4稳定.
- 女性TT4较高;白人参与者TSH较高.
- 新的间隔重新分类了48.5%的亚临床甲状腺功能低下症和31.2%的亚临床甲状腺功能过高症病例.
结论:
- 年龄,性别和种族特定的参考间隔对于准确的甲状腺疾病诊断至关重要.
- 这些发现支持在定义和管理甲状腺疾病方面形成共识.
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