维生素D和骨密度,几何学和微观建筑在男性军人新兵:一个观察性研究和随机对照试验
Thomas J O'Leary1,2, Rachel M Izard3, Sarah Jackson1
1Army Health and Performance Research, Army Headquarters, Andover, United Kingdom.
概括
维生素D代谢物与军事训练期间的骨结构变化相关. 然而,维生素D补充剂并没有影响这些新兵的骨适应.
科学领域:
- 骨代谢和生理学的骨代谢和生理学
- 营养生物化学 营养生物化学
- 体育医学和军事健康 运动医学和军事健康
背景情况:
- 军事训练对骨施加了很大的压力,增加了骨应力损伤的风险.
- 维生素D在骨健康中起着至关重要的作用,但其对强度体育训练期间骨适应的具体影响尚未完全理解.
研究的目的:
- 调查维生素D代谢物与军人新兵骨结构和密度之间的关联.
- 为了确定维生素D补充剂对军训期间骨适应的作用.
主要方法:
- 一个横截面的观察性研究 (研究1) 和一个随机对照试验 (研究2) 涉及男性英国陆军新兵.
- 测量循环维生素D代谢物和高分辨率外围定量计算断层扫描 (HRpQCT) 评估了骨结构和密度.
- 第二项研究涉及12周补充维生素D (口服或模拟阳光) 或安慰剂.
主要成果:
- 在总25-基维生素D[25(OH) D]或维生素D受体多态和骨参数之间没有发现任何关联.
- 特定的维生素D代谢物 (1,25(OH) 2D,24,25(OH) 2D) 和它们的比例与骨几何和微观架构有关.
- 维生素D补充剂并没有改变骨对训练的适应性,尽管训练本身引起了椎骨和皮质骨参数的变化.
结论:
- 循环维生素D代谢物与军人新兵的骨特征有关.
- 补充维生素D似乎不会改变骨对军事训练机械负荷的适应性反应.
- 可能需要进一步的研究来阐明维生素D在预防身体活跃人群的骨压力损伤中的确切作用.
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