活疫苗接种和心血管结果:一个全国性的韩国研究
Sooji Lee1,2, Kyeongmin Lee1,3, Jiyeon Oh1,2
1Center for Digital Health, Medical Science Research Institute, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, 23, Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, South Korea.
活疫苗接种显著降低了心血管事件的风险,包括重大心血管事件和心力衰竭. 这种疫苗接种可以作为一种公共卫生策略,以减少心血管疾病负担和相关死亡率.
科学领域:
- 心脏病学 心脏病学
- 免疫学 免疫学 免疫学
- 公共卫生 公共卫生
背景情况:
- 疹疹感染与心血管事件有关,但活疹疫苗对心血管结果的影响仍未得到充分研究.
- 需要进行大规模的研究来澄清黄斑疫苗接种与心血管健康之间的关系.
研究的目的:
- 在大量人群中调查活疫苗接种与各种心血管事件的风险之间的联系.
- 评估活疫苗对心血管的长期益处.
主要方法:
- 在2012-2021年期间,在韩国进行了一项基于人口的队列研究 (n=2,207,784),年龄≥50岁.
- 基于倾向性得分的重叠权重和Cox比例危险模型被用于分析疫苗接种后发生的心血管事件的结果.
- 限制平均存活时间 (RMST) 计算以评估长期影响.
主要成果:
- 活疫苗接种与整体心血管事件 (HR 0.77) 和特定疾病 (如MACE,心力衰竭和脑血管疾病) 的风险降低有关.
- 保护作用持续长达8年,最显著的减少是在接种疫苗后2-3年观察到的.
- 在男性,年轻人 (<60岁),那些不健康的生活方式和较低社会经济地位的群体中,好处更为明显.
结论:
- 活疫苗证明了潜在的心血管益处,表明其作为公共卫生干预措施的实用性.
- 这种疫苗接种策略可以帮助减轻心血管疾病负担并解决健康差异.
- 进一步的研究可能会探索这些保护性心血管效应背后的机制.
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