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Updated: May 15, 2025

Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation
15:04

Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation

Published on: January 19, 2019

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评估有效性和毒性终点之间的相关性在贝叶斯最佳II期设计的性能中的作用

Xun Xu1, Ying Yuan2, J Jack Lee2

  • 1Department of Biostatistics and Data Science, School of Public Health, University of Texas, Houston 77030, TX, United States; Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston 77030, TX, United States.

Contemporary clinical trials
|May 5, 2025
PubMed
概括

了解疗效与毒性之间的相关性对于贝叶斯最佳II期 (BOP2) 设计至关重要. 这项研究揭示了相关性如何影响统计能力和I型错误,为准确的临床试验规划提供了指导.

关键词:
贝叶斯适应式设计是贝叶斯的适应式设计.数据分析阶段 数据分析阶段设计阶段 设计阶段疗效与毒性之间的权衡.这就是Phi系数的系数.灵敏度分析是一种灵敏度分析.

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