原蛋白补充剂对皮肤衰老的影响:随机对照试验的系统审查和元分析
Seung-Kwon Myung1, Yunseo Park2
1Department of Cancer AI & Digital Health, National Cancer Center Graduate School of Cancer Science and Policy; 323 Ilsan-ro, Ilsandong-gu, Goyang, Gyeonggi-do, 10408, Republic of Korea; Cancer Epidemiology Branch, Division of Cancer Data Science, National Cancer Center Research Institute; 323 Ilsan-ro, Ilsandong-gu, Goyang, Gyeonggi-do, 10408, Republic of Korea; Department of Family Medicine and Center for Cancer Prevention and Detection, Hospital, National Cancer Center; 323 Ilsan-ro, Ilsandong-gu, Goyang, Gyeonggi-do, 10408, Republic of Korea.
The American journal of medicine
|May 5, 2025
概括
原蛋白补充剂对皮肤衰老没有被证明的好处. 一项研究的审查发现,皮肤水分,弹性和纹的感知改善与研究质量和资金来源有关,而不是补充剂本身.
科学领域:
- 皮肤病学 皮肤病学
- 营养科学 营养科学
- 基于证据的医学基于证据的医学.
背景情况:
- 原蛋白补充剂被广泛推销为对皮肤的抗衰老作用.
- 之前的研究并没有基于资金和研究质量全面分析随机对照试验 (RCT).
- 这些因素可能会引入偏见并影响报告的结果.
研究的目的:
- 对皮肤衰老的原蛋白补充剂进行RCT的元分析.
- 调查研究资金来源和质量对报告的原蛋白补充剂疗效的影响.
- 确定原蛋白补充剂在预防或治疗皮肤衰老方面的临床证据.
主要方法:
- 在PubMed,Embase和Cochrane图书馆进行系统的文献搜索,截至2024年6月14日.
- 对23项涉及1474名参与者的RCT进行的元分析.
- 根据研究资金和方法质量进行了子组分析.
主要成果:
- 总体而言,分析表明皮肤水分,弹性和纹的改善.
- 亚组分析显示,在没有制药资金的研究中或在高质量的研究中没有显著的影响.
- 低质量的研究和由制药公司资助的研究报告了显著的改善,特别是在弹性方面.
结论:
- 目前的临床证据不支持原蛋白补充剂对皮肤衰老的有效性.
- 在一些研究中观察到的明显好处可能归因于资金来源和研究质量的偏见.
- 需要进一步进行高质量的独立研究,以确定原蛋白补充剂的任何潜在作用.
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