识别人类的毒力学变异性:当前知识的系统证据地图.
Annika Boye Petersen1, Lea Bredsdorff1, Natasha Tahir2
1National Food Institute, Technical University of Denmark (DTU), 2800, Lyngby, Denmark.
Regulatory toxicology and pharmacology : RTP
|May 5, 2025
概括
目前的化学风险评估依赖于人类毒动力学 (TD) 变化的默认不确定性因子 (UF). 这项研究发现有限的数据来改进UF,强调需要标准化的方法来评估TD变异性.
科学领域:
- 毒理学 毒理学 毒理学
- 环境健康 环境健康
- 药理学 药理学是指药理学的学科.
背景情况:
- 化学风险评估通常使用3.16的默认不确定因素 (UF) 来考虑人类毒动力学 (TD) 变化.
- 精制这种UF需要对人类TD变异性的强有力的经验数据,与毒动力学 (TK) 影响分开.
研究的目的:
- 系统地绘制人类TD变异性的证据.
- 为了评估提炼3.16的默认UF对TD波动性的可行性.
主要方法:
- 通过从2004年到2023年搜索PubMed和Web of Science,创建了一个系统证据地图 (SEM).
- 纳入标准侧重于研究,在这些研究中,可以从TK中定量分离TD变异性.
- 检索了2408项研究,其中23项体外研究满足了评估人类TD变异性的标准,只有7项提供了定量TD变异因子 (TDVF).
主要成果:
- 没有任何体内研究符合纳入标准.
- 这23项体外研究揭示了异质数据和多种方法,使比较复杂化.
- 七项研究提供了定量TDVF,其中一些研究表明3.16的默认FU可能无法充分覆盖人类的变异性,而另一些研究则表示可能会.
结论:
- 对于评估人类TD变异性而言,实证数据非常稀缺,特别是那些不包括TK影响的数据.
- 现有研究中的异质性和方法上的差异阻碍了对默认UF的改进.
- 确定TDVF的标准化方法对于未来的评估至关重要.
关键词:
化学风险评估 化学风险评估 化学风险评估化学特异性评估因子的化学特异性评估因子数据驱动的有毒动力学可变性因子默认的不确定性因素是默认的不确定性因素.人类的可变性 人类的可变性个体间的变异性.毒动力学 毒动力学 毒动力学更多相关视频
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