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Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.
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基于成分的中医药PEBL通过准FXR来降低ACE2水平来减少病毒引起的急性肺损伤.

Liling Yang1, Xiangjun Zhou2, Junshan Liu3

  • 1Third Level Research Laboratory of State Administration of Traditional Chinese Medicine, Guangdong Provincial Key Laboratory of Chinese Medicine Pharmaceutics, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China; Department of Pharmacy, Binhaiwan Central Hospital of Dongguan, Dongguan 523900, China.

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菲利林-埃莫丁-贝卡林-利基 (PEBL) 通过抑制FXR/ACE2通路,有效治疗病毒性急性肺损伤 (ALI). 这种以成分为基础的中医药减少了炎症,并改善了病毒性肺炎模型的结果.

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在ACE2中,ACE2是ACE2.急性肺损伤是什么?急性肺损伤是什么?细胞因子风暴导致细胞因子风暴在 FXR 和 FXR 之间.皮布尔 (Pebble) 是一个小石头.病毒 病毒 病毒

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科学领域:

  • 药理学 药理学是指药理学的学科.
  • 免疫学 免疫学 免疫学
  • 传统中国医药 传统中国医药

背景情况:

  • 急性肺损伤 (ALI) 构成了严重的临床挑战,治疗选择不足.
  • 传统中医 (TCM) 具有潜力,但复杂的配方阻碍了采用;基于成分的中医 (CCM) 提供了一个可行的替代方案.
  • 菲利林-埃莫丁-贝卡林-利基里丁 (PEBL),一种来自梁家山的CCM,表现出抗炎性质,但其在病毒ALI中的有效性尚不清楚.

研究的目的:

  • 研究PEBL对病毒性急性肺损伤 (ALI) 的治疗作用.
  • 阐明PEBL在治疗病毒ALI的基础分子机制.
  • 在病毒性呼吸道感染的临床前模型中评估PEBL的疗效.

主要方法:

  • 通过分析细胞因子生产,巨菌透,肺损伤和死亡率,评估PEBL在Poly (I: C) 诱导的ALI模型中的疗效.
  • 采用生物信息学和网络药理学来确定治疗点和信号通路.
  • 在细胞培养 (RAW264.7),斑马鱼和A型流感 (PR8) 和SARS-CoV-2 Omicron (XBB) 的小鼠模型中验证的分子机制诱导了ALI.

主要成果:

  • PEBL治疗显著减轻了Poly (I:C) 诱导的ALI,减少了炎症标志物和死亡率.
  • 虚拟查确定了farnesyl X受体 (FXR) 和血管素转化酶2 (ACE2) 作为关键标.
  • 在病毒ALI模型 (PR8和XBB) 中,PEBL降低了FXR的调节,抑制了它与ACE2促进体的结合,抑制了NF-κB激活和随后的细胞因子风暴.

结论:

  • 通过抑制FXR/ACE2信号轴,PEBL显示出对病毒ALI的保护作用.
  • PEBL减少了巨细胞透,细胞因子风暴和炎症损伤,改善了病毒ALI.
  • PEBL显示出作为病毒急性肺损伤的治疗候选者的潜力.