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Hanxiao Shen¹, Ding Wang¹, Yuxin Huang¹

¹Institute of Pharmaceutical Innovation, Hubei Province Key Laboratory of Occupational Hazard Identification and Control, School of Medicine, Wuhan University of Science and Technology, Wuhan 430065, China.

|May 5, 2025

概括

像TCDF这样的持久有机污染物破坏了肠道微生物和新陈代谢. 补充特定的托芬代谢物 (3-IAld和IA) 保护小鼠从TCDF.

科学领域:

环境毒理学环境毒理学
肠道微生物组研究研究
代谢学和宿主微生物相互作用.

背景情况:

持久性有机污染物 (POP) 影响肠道微生物群和宿主代谢.
饮食暴露是POPs的主要途径.
2,3,7,8-四二硫 (TCDF) 是一个特别令人担忧的POP.

研究的目的:

研究TCDF对肠道微生物群和宿主代谢过程的影响.
为了确定TCDF暴露引起的特定微生物和代谢变化.
评估托代谢物对抗TCDF诱导的损伤的治疗潜力.

主要方法:

用于基因表达分析的RNA测序 (RNA-seq).
甲基因组学分析以分析肠道微生物组成.
代谢分析分析以量化代谢物水平.
鼠标模型用于评估毒性和治疗干预措施.

主要成果:

TCDF显著改变了托代谢,脂质通路和免疫功能.
TCDF降低了Mucispirillum schaedleri和关键的托芬代谢物 (3-IAld, IA) 的丰度.
补充3-IAld和IA改善了TCDF诱导的肝毒性,肠道炎症,并增强了肠道屏障功能.

结论:

暴露于TCDF会破坏肠道微生物群和宿主代谢平衡.
托方代谢物 (3-IAld和IA) 在缓解TCDF诱导的损伤方面显示出治疗潜力.
准肠道微生物衍生的代谢物可能提供针对POP诱导的健康影响的策略.

关键词:

2,3,7,8-四二二硫的使用情况.我们的肠道微生物群.印度尔衍生品的印度尔衍生它们是Mucispirillum的表格.托芬代谢的代谢方式

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