在核中的多巴胺D3受体调节了小鼠的阿片类药物摄入和寻找

Meng-Die Yang1, Xing-Fang Cun1, Ning Wu1

  • 1Beijing Key Laboratory of Neuropsychopharmacology, Beijing Institute of Pharmacology and Toxicology, 27th Taiping Road, Beijing 100850, China.

概括

选择性多巴胺受体D3 (Drd3) 抗剂通过向核聚集体 (NAc) 来减少阿片类药物的使用. 阻断NAc中的Drd3抑制了VTA多巴胺神经元的活动,减少了寻找和摄入吗啡.

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