在Cochrane干预审查中纳入非随机证据:一个范围审查
Emma Axon1, Afroditi Kanellopoulou2, Sofia Tsokani3
1Cochrane Central Executive Team.
Journal of clinical epidemiology
|May 5, 2025
概括
科克莱恩的作者
科学领域:
- 基于证据的医学是基于证据的医学.
- 系统审查是系统的审查.
- 健康研究方法的方法论.
背景情况:
- 干预的非随机研究 (NRSI) 在随机对照试验 (RCT) 不可行时提供真实世界的见解.
- 科克兰评论是综合健康证据的关键来源.
研究的目的:
- 调查Cochrane作者如何将NRSI的证据纳入他们的评论.
- 评估随着时间的推移使用NRSI指南的变化.
- 为了确定需要进一步支持的领域,审查作者.
主要方法:
- 对2019年和2023年发表的Cochrane评论进行范围审查.
- 提取NRSI分析,偏差风险评估和遵守"柯克伦手册"指南的数据.
- 在非随机干预研究中利用偏差风险 (ROBINS-I) 工具.
主要成果:
- 观察到对NRSI指导的遵守程度较低.
- 只有不到一半的评论 (41%) 证明了纳入NRSI是合理的.
- 只有29%的人优先考虑调整后效果措施,29%的人使用ROBINS-I.
- 在2019年至2023年期间,人们注意到遵守的改善,但仍然很低.
结论:
- 科克莱恩作者使用NRSI指南需要改进.
- 预计对包括NRSI证据在内的审查需求将增加.
- 科克兰应该加强对纳入NRSI的支持和指导.
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