奥兰沙平用于管理抗血管原氨酸激酶抑制剂的副作用
Regina M Koch1, Miguel Muniz2, Candy S Peskey2
1Department of Internal Medicine, Mayo Clinic, Rochester, MN, US.
Journal of pain and symptom management
|May 5, 2025
概括
奥兰沙平有效地控制了氨酸激酶抑制剂 (TKIs) 的副作用,包括恶心,吐,厌食症和失眠. 这项研究表明,奥兰扎平是对这些繁重的TKI诱导症状的有希望的治疗方法.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
- 临床医学 临床医学
背景情况:
- 氨酸激酶抑制剂 (TKIs) 通常会导致负担重重的副作用.
- 奥兰沙平用于化疗引起的症状,但其对TKI副作用的疗效尚未得到充分证实.
研究的目的:
- 为了评估 olanzapine 在控制 TKI 诱导的恶心,吐,厌食症,减肥和失眠方面的有效性.
主要方法:
- 在梅奥诊所接受过 olanzapine 和 TKIs (lenvatinib,cabozantinib,axitinib,tivozanib) 治疗的 60 名患者的回顾性评估.
- 临床笔记分析了症状变化 (改善,恶化,稳定) 在开始 olanzapine 的三个月内.
主要成果:
- 观察到的改善率很高:85%的恶心没有吐,93%的恶心有吐,74%的食欲,85%的睡眠.
- 在之前减肥的患者中,50%的体重增加,26%的体重稳定.
- 只有4名患者因副作用而停止服用 olanzapine.
结论:
- 奥兰沙平在缓解与氨酸激酶抑制剂治疗相关的常见副作用方面表现出显著的有效性.
- 建议进行进一步的前性研究,以证实这些发现,并将奥兰扎宾作为标准治疗选择.
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