幼儿园年龄参与大规模药物管理:分析对社区范围内的杆菌病控制的影响
John R Ellis1, Roy M Anderson1
1Department of Infectious Disease Epidemiology, School of Public Health, Faculty of Medicine, White City Campus, Imperial College London, London, United Kingdom.
概括
将学龄前儿童 (PSAC) 纳入用于治疗杆菌病的大规模药物管理 (MDA) 中,可以降低儿童发病率. 然而,这种包括可能不会显著增加作为公共卫生问题 (EPHP) 消除疾病的可能性.
科学领域:
- 热带医学是一种热带医学.
- 寄生虫学的寄生虫学
- 公共卫生 公共卫生
背景情况:
- 儿童时期的杆菌感染是一个重大的公共卫生问题,导致相当大的发病率.
- 为学龄前儿童 (PSAC) 开发了一种新的普拉齐量子配方,促使对大规模药物管理 (MDA) 计划的影响进行评估.
- 了解将PSAC纳入MDA的全社区影响对于有效控制杆菌病至关重要.
研究的目的:
- 评估将学龄前儿童 (PSAC) 纳入大规模药物管理 (MDA) 的影响,对社区一级的杆菌病传播和发病率的影响.
- 评估将PSAC纳入MDA计划是否提高了实现消除作为公共卫生问题 (EPHP) 的可能性.
主要方法:
- 采用了一种史基托索米亚症传播的数学模型.
- 进行了模拟,以估计达到EPHP的概率.
- 使用"虫年"指标量化儿童发病率,测量到5岁的累积感染负担.
主要成果:
- 将PSAC纳入MDA中始终降低了儿童发病率.
- 然而,包括PSAC并没有显著增加实现EPHP的可能性.
- 一个社区内的瘤感染的年龄分布是影响MDA计划有效性和年龄组优先级的关键因素.
结论:
- 决策者应该注意,将PSAC纳入MDA可能不足以达到世界卫生组织的EPHP目标.
- 在孩子们开始上学之前减少累积的虫感染负担,可以带来显著的长期效益.
- 专注于儿童早期的干预可以提高MDA计划对杆菌病控制的整体影响.
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