在挪威HUNT研究中,在11年内跟踪血清25-基维生素D水平
Xiao-Mei Mai1, Marit Næss2,3, Kristin S Sætermo2,3
1Department of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, Norway.
Journal of epidemiology and community health
|May 5, 2025
概括
在成人中,血清25-基维生素D (25(OH) D) 水平在11年内显示中度跟踪. 诸如性别,BMI,吸烟,教育,酒精和补充剂等因素影响维生素D状态,表明需要重复测量.
科学领域:
- 内分泌学 在内分泌学.
- 营养科学 营养科学
- 公共卫生 公共卫生
背景情况:
- 血清25-基维生素D (25(OH) D是维生素D状态的关键指标,受到阳光照射和饮食的影响.
- 维生素D的状态与各种健康结果有关,需要了解其长期稳定性.
- 在一般人群中长时间追踪25...OH) D水平仍然是一个感兴趣的领域.
研究的目的:
- 在挪威的成年人群中,研究了在11年的时间里对血清25(OH) D水平的跟踪.
- 为了确定随着时间的推移与血清25OH) D水平相关的人口,生活方式和遗传因素.
- 评估单个血清25(OH) D测量对长期健康评估的可靠性.
主要方法:
- 纵向研究设计使用来自11年的特伦德拉格健康研究 (HUNT2和HUNT3) 的数据.
- 在3511名成年人中使用化学发光试验测量血清25(OH) D水平,并对批量和季节性影响进行校准.
- 统计分析包括相关系数,类内相关系数 (ICC),变化系数 (CV) 和多变量线性回归.
主要成果:
- 在这两项调查中,观察到血清25(OH) D水平的中等相关性 (r=0.50) 和ICC (0.64).
- 大约43%的参与者在11年期间保持了他们的维生素D状态类别.
- 与较低的25-OH-D相关的因素包括男性性别,较高的BMI和吸烟;高等教育,适度饮酒和维生素D补充剂与较高水平有关.
结论:
- 血清25(OH) D水平在11年内表现出适度的跟踪,这表明从单次测量中获得的长期稳定性有限.
- 个人维生素D状态可能会随着时间的推移而波动,受到各种因素的影响.
- 建议重复测量血清25(OH) D,以更准确地评估长期维生素D状态及其对健康的影响.
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