肥胖和自身免疫性流行病:免疫代谢的作用
Alessandra Colamatteo1, Clorinda Fusco1, Alessandro Matarese2,3
11Treg Cell Lab, Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di Napoli "Federico II," Napoli, Italy;
Annual review of nutrition
|May 5, 2025
概括
肥胖通过促进慢性炎症和免疫失调而加剧自身免疫性疾病. 了解这些免疫代谢联系对于开发两种疾病的新疗法至关重要.
科学领域:
- 免疫学 免疫学 免疫学
- 代谢障碍 代谢障碍 代谢障碍
- 这是一种自身免疫力.
背景情况:
- 越来越多的证据表明,肥胖与自身免疫性疾病的患病率增加有关.
- 肥胖会导致代谢失调和慢性轻度炎症.
- 脂肪组织充当免疫代谢器官,分泌影响免疫反应的脂素.
研究的目的:
- 审查连接肥胖和自身免疫的免疫代谢病理机制.
- 探索肥胖-自身免疫性流行病的潜在治疗策略.
主要方法:
- 流行病学和机理学研究的文献综述.
- 对脂肪组织和脂蛋白在免疫耐受性中的作用的分析.
- 在肥胖和自身免疫的背景下讨论"加速器假设".
主要成果:
- 肥胖引起的脂肪组织功能障碍促进慢性炎症.
- 炎症可能导致自身免疫耐受性丧失和自身炎症.
- 在肥胖个体中,循环自反应性T细胞可能会失去调节控制.
结论:
- 肥胖和自身免疫有着复杂的免疫代谢基础.
- 针对免疫代谢途径可能会提供新的治疗机会.
- 解决肥胖-自身免疫性流行病需要综合公共卫生方法.
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