血液病入院患者的静脉血栓栓塞风险:一项回顾性研究
Stefano Cordella1,2,3, Valeria Coluccio1, Riccardo Cuoghi Costantini3,4
1Hematology Unit, Azienda Ospedaliero-Universitaria, 41124, Modena, Italy.
Annals of hematology
|May 5, 2025
概括
患有血液性恶性瘤的患者面临静脉血栓栓塞事件 (VTE) 的风险. 现有的风险评估模型 (RAMs) 在这个群体中表现不佳,突出了需要量身定制的VTE预测工具的需求.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 血栓形成的研究研究
背景情况:
- 患有血液性恶性瘤的患者有明显的静脉血栓栓塞事件 (VTE) 风险.
- 目前存在的VTE和出血风险评估模型 (RAM) 在这个特定的患者群体中没有得到验证.
- 缺乏经过验证的RAM来预测血液性恶性瘤患者住院期间的VTE风险.
研究的目的:
- 评估住院血液病患者中静脉瘤和出血事件 (HE) 的发生率.
- 评估这个队列中药理学预防的使用情况.
- 在血液病患者中测试现有的RAM (VTE的Padua预测得分和HE的改善出血得分) 的性能.
主要方法:
- 在首次入院后,对514名血液病患者进行了观察性研究.
- 评估VTE和HE发生率.
- 低分子量肝素 (LMWH) 预防的评估.
- 测试帕多瓦预测得分 (PPS) 和改善出血得分 (IBS).
主要成果:
- 静脉瘤发作发生率为3.11%,高血压发作发生率为1.75%.
- 大多数事件发生在没有接受预防的患者中.
- 帕多瓦预测得分 (PPS) 在预测该人口的VTE风险方面表现不佳.
- 多变量分析显示,急性白血病诊断和预防作为VTE预测因子的统计学意义丧失.
结论:
- 现有的RAMs不足以预测血液恶性瘤患者的VTE和HE.
- 需要进一步的研究来开发和验证为这种高风险人群量身定制的RAM.
- 对于患有血液性恶性瘤的患者,需要改进VTE管理策略.
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