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乳腺癌免疫微环境类型的代谢表征和基于放射学的复合模型使用F-FDG PET/CT

Yuan Gao^1,2, Zijian Fu¹, Xiaojuan Zhu³

¹Department of Nuclear Medicine, Peking University First Hospital, Beijing, China.

European journal of nuclear medicine and molecular imaging

|May 5, 2025

概括

乳腺癌中的瘤免疫微环境类型 (TIMTs) 在18F-FDG PET/CT上表现出明显的代谢特征. 放射学模型准确预测TIMT-II,可能识别对免疫检查点抑制剂 (ICI) 的反应者.

科学领域:

在瘤学瘤学.
放射学放射学是一门学科.
免疫学免疫学免疫学

背景情况:

瘤免疫微环境类型 (TIMTs) 是复杂的,对免疫检查点抑制剂 (ICI) 的影响反应.
准确识别TIMT对于预测乳腺癌治疗结果至关重要.

研究的目的:

通过使用18F-FDG PET/CT.来研究乳腺癌中不同TIMT的代谢特征.
开发基于放射学的预测模型来分类TIMT.

主要方法:

对207名乳腺癌患者 (211个病变) 的回顾性审查,这些患者接受了18F-FDG PET/CT.
评估编程死亡配体1 (PD-L1) 和瘤透淋巴细胞 (TILs),以定义TIMTs (TIMT-I至TIMT-IV).
对代谢参数 (SUVmax,TLR) 的分析和基于放射学的复合预测模型的开发.

主要成果:

在HER2+ (64%) 和三阴性 (63%) 乳腺癌中,TIMT-II是普遍存在的.
在TIMT-II和其他类型 (例如TIMT-I,TIMT-III) 之间观察到显著的代谢差异.
瘤与肝脏SUV比率 (TLR) 和诺丁汉等级是TIMT-II的独立预测因素. 一个复合模型在测试组中实现了0.86的AUC.

结论:

在不同的TIMT中存在不同的代谢概况,TIMT-II显示了较高的代谢活性.
一个基于放射学的复合模型证明了TIMT-II的高预测准确性.
这种模型有可能用于查可能对ICI有反应的患者.

关键词:

18F-FDG 关于PET/CT 的研究乳腺癌乳腺癌乳腺癌免疫检查点抑制剂 (ICI) 免疫检查点抑制剂无线电学 (Radiomics) 是一种无线电学.瘤免疫微环境类型 (TIMTs)

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