帕金森病患者中脑半球间同步受损 帕金森病患者中脑半球间同步受损 帕金森病患者中脑半球间同步受损 帕金森病患者中脑半球间同步受损 帕金森病患者中脑半球间同步受损
Xinhui Wang1, Peng Liu1, Qiurong Yu1,2
1The Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Brain imaging and behavior
|May 5, 2025
概括
帕金森病 (PD) 的认知衰退与大脑半球之间的功能连接减少有关. 在特定的部和部区域的较低连接性可能预测PD患者的认知恶化.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 医疗成像医学成像
背景情况:
- 认知能力下降是帕金森病 (PD) 中普遍存在的非运动性症状,影响患者在疾病的所有阶段.
- 在PD中认知变化的神经支柱尚未完全理解,半球不对称性与认知障碍有关.
- 研究半球间协调提供了一个潜在的途径,以阐明在PD认知进展背后的机制.
研究的目的:
- 通过评估功能性半球间协调来探索帕金森病认知进展的神经机制.
- 使用神经影像标志物,区分具有稳定的认知表现 (sPD) 的帕金森病患者和具有渐进性认知障碍 (pPD) 的患者.
- 检查功能性半球间协调和PD的认知状态之间的关系.
主要方法:
- 招募了54名PD患者 (29名sPD,25名pPD) 和18名健康对照 (HC).
- 获得的T1加权和静止状态功能磁共振成像 (fMRI) 数据.
- 利用Voxel-mirrored Homotopic Connectivity (VMHC) 分析来评估灰色物质体积的功能性半球间协调和基于voxel的形态学.
主要成果:
- 与稳定认知表现 (sPD) 组相比,渐进性认知障碍 (pPD) 组在中圈 (MTG),中圈 (MOG) 和上圈 (STG) 中显示出明显较低的Voxel-mirrored Homotopic Connectivity (z-VMHC).
- 在三个组 (pPD,sPD,HC) 之间没有发现灰质体积的显著差异.
- 在MTG和MOG中的z-VMHC值和蒙特利尔认知评估 (MoCA) 在随访时的得分之间观察到正相关性,表明连接性和认知功能之间存在联系.
结论:
- 在MTG,MOG和STG中功能性半球间协调减少可能作为潜在的神经成像生物标志物,以区分帕金森病中渐进和稳定的认知衰退.
- 这些发现有助于理解潜在的神经机制认知表现和PD的进展.
- VMHC分析为评估与PD等神经退行性疾病中的认知变化相关的大脑连接性改变提供了有价值的工具.
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