从诊断到治疗的最小变化疾病在怀孕期间
Petra Bolt1, Iana Adamović2, Matija Horaček2
1University of Zagreb School of Medicine, Šalata 2, 10000, Zagreb, Croatia. petra.bolt@gmail.com.
CEN case reports
|May 5, 2025
概括
最小变化疾病 (MCD) 可以在怀孕期间引起性综合征. 脏活检对于诊断MCD等初级脏疾病至关重要,指导用类固醇和塔克罗利斯有效治疗缓解.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 产科和妇科 产科和妇科
背景情况:
- 孕前是怀孕期间性综合征的最常见原因.
- 初级脏疾病不太常见,但是在孕妇中引起脏综合征的重要原因.
研究的目的:
- 报告怀孕期间呈现为综合征的最小变化疾病 (MCD) 病例.
- 突出脏活检在患有初级脏疾病的孕妇患者的诊断和治疗影响.
主要方法:
- 一个案例报告,一名33岁的孕妇在怀孕22周时出现了性综合征.
- 诊断工作包括脏活检,揭示最小变化疾病与podocyte脚过程消除.
- 治疗开始于静脉注射甲基prednisolone,其次是口服普得尼松,随后是复发和分娩后管理与tacrolimus.
主要成果:
- 患者通过使用类固醇实现了初步缓解,但在妊娠37周后复发,由于橄水和胎儿生长限制,需要引发分娩.
- 新生儿患有败血症,并成功治疗.
- 产后,母亲发展了类固醇耐药性,通过塔克罗利斯治疗实现了缓解.
结论:
- 脏活检对于准确诊断怀孕期间的初级脏疾病至关重要,将其与产前症区分开来.
- 及时和准确的诊断有助于制定适当的治疗策略,从而成功管理疾病和缓解疾病.
- 这一案例强调了考虑和调查患有性综合征的孕妇初级病理学的重要性.
相关概念视频
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
98
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
98
Chronic Pancreatitis II: Collaborative Care
46
The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
Assessment:
46
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
219
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
219
Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids
84
Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
84
Inflammatory Bowel Disease IV: Pharmacological Management
79
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Pharmacologic...
79


