血清水平降低与牙周炎III-IV阶段的氧化应激之间的潜在关系
Mehmetcan Uytun1, Recep Orbak2, Ahmet Kızıltunç3
1Department of Periodontology, School of Dentistry, Muğla Sıtkı Koçman University, Muğla, 48000, Turkey. mehmetcanuytun@mu.edu.tr.
Biological trace element research
|May 5, 2025
概括
牙周炎与增加的氧化应激和较低的水平有关. 可能是牙周病的关键生物标志物,与疾病严重程度和氧化状态有很强的相关性.
科学领域:
- 口腔健康 口腔健康
- 生物化学 生化学
- 营养科学 营养科学
背景情况:
- 牙周炎是一种普遍的炎症性疾病,影响牙和支结构.
- 氧化应激在各种慢性疾病的发病过程中发挥着作用,包括牙周炎.
研究的目的:
- 调查牙周炎与氧化应激标志物之间的关系:总氧化剂状态 (TOS) 和总抗氧化剂状态 (TAS).
- 评估血清水平与牙周炎和氧化应激标志物的相关性.
主要方法:
- 一项涉及122名参与者的病例控制研究 (61名患有牙周炎,61名健康对照).
- 测量血清TOS,TAS和水平.
- 统计分析包括单变量和多变量逻辑回归.
主要成果:
- 与健康个体相比,牙周炎患者的TOS显著更高,TAS较低 (p < 0.001).
- 在牙周炎组,血清水平显著降低 (p < 0.001).
- 后勤回归证实了较低的水平和牙周炎之间的显著相关性.
结论:
- 牙周炎与氧化状态的不平衡有关 (TOS升高,TAS降低).
- 较低的血清水平与牙周炎显著相关.
- 可以作为牙周病的宝贵生物标志物,反映疾病活性和氧化应激.
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