久坐不动行为与痴呆症之间的关联:对队列研究的系统审查和元分析
Jinyan Luo1, Yiping Huang1, Gangqiang Gao1
1Institute for Hospital Management, Tsinghua University, Shenzhen International Graduate School (SIGS), Shenzhen, Guangdong, 518055, China.
BMC psychiatry
|May 5, 2025
概括
久坐不动的行为 (SB) 与更高的痴呆风险有关. 然而,当SB被具体定义为计算机使用时间时,没有观察到这种关联.
科学领域:
- 神经学 神经学
- 公共卫生 公共卫生
- 老年学是一门学科.
背景情况:
- 久坐不动的行为 (SB) 越来越被认为是一个公共卫生问题.
- 了解SB和痴呆症之间的联系对于预防策略至关重要.
研究的目的:
- 评估一般成年人群中静坐行为和痴呆症风险之间的关联.
- 综合了多项关于这种关系的队列研究的证据.
主要方法:
- 进行了对队列研究的系统审查和元分析.
- 数据从PubMed,科学网,Embase和Cochrane图书馆提取到2024年11月3日的数据.
- 使用随机或固定效应模型计算了聚合危险比率 (HRs) 和95%置信区间 (CI).
主要成果:
- 包括10项队列研究,其中9项被认为是高质量的.
- 总体而言,久坐的行为与痴呆症风险增加有关 (汇总HRs,1.17;95%CI,1.06-1.29).
- 观看电视的时间增加了31%的痴呆风险 (汇总HRs,1.31;95%CI,1.25-1.37),而电脑使用时间没有显著的关联 (汇总HRs,0.89;95%CI,0.73-1.09).
结论:
- 久坐不动的行为是痴呆症的重要危险因素.
- 久坐不动行为和痴呆症之间的关联可能因特定类型的久坐不动活动而异.
- 需要进一步的研究来澄清不同形式的久坐行为和痴呆风险之间的细微关系.
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