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神经发育期间的肠-免疫-大脑相互作用:从以大脑为中心的角度到多系统的角度

Greta Volpedo¹, Antonella Riva², Lino Nobili^1,3

¹Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, IRCCS Istituto "Giannina Gaslini", Via Gerolamo Gaslini 5, Genoa, 16147, Italy.

|May 5, 2025

概括

神经发育障碍和可能源于肠道健康. 针对肠道微生物群和免疫系统提供了超越症状管理的新治疗策略.

科学领域:

神经科学是一个神经科学.
免疫学免疫学免疫学
微生物学微生物学

背景情况:

神经发育障碍 (NDD) 和综合征具有复杂的神经生物学起源.
目前对NDD和的治疗主要是治疗症状,未能解决根本原因,并留下未满足的临床需求.

研究的目的:

探索肠-免疫-大脑轴在NDD和中的作用.
突出微生物失调和免疫信号作为神经病理的贡献者.
研究微生物管理和免疫调节作为潜在的治疗策略.

主要方法:

审查有关肠道微生物群对大脑发育和功能影响的新兴证据.
对肠-免疫-大脑轴内的相互作用进行分析.
探索微生物和免疫干预的治疗潜力.

主要成果:

肠道微生物群和免疫反应显著影响大脑发育和功能.
微生物失生症和免疫信号与NDD和的病原发生有关.
肠-免疫-大脑轴代表了从纯粹以大脑为中心的对这些疾病的观点的范式转变.

结论:

对肠-免疫-大脑轴的综合视图为NDD和提供了新的见解.
这种观点建议创新的生物标志物和治疗策略,针对这些疾病的根本原因.

关键词:

更多关于 ADHD ADHD 的文章自闭症自闭症自闭症是一种病.我们的肠道微生物群.神经发育神经发育

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