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便微生物组特征和体重变化对癌症缓解症治疗的反应

Rima Nasrah^1,2,3, Mary Kanbalian¹, Christina Van Der Borch¹

¹McGill Cancer Nutrition Rehabilitation Program, Jewish General Hospital (CNR-JGH), Montreal, Canada.

Journal of cachexia, sarcopenia and muscle

|May 6, 2025

概括

肠道微生物群的多样性和拉克诺斯皮拉的丰富性可以预测进行营养干预的癌症缓解症患者的体重变化. 基线时更高的多样性和Lachnospira表明对饮食支持的反应更好.

科学领域:

在瘤学瘤学.
微生物组研究微生物组研究
营养科学营养科学

背景情况:

癌症缓解症会导致显著的体重和肌肉损失,影响患者的治疗结果.
营养干预改善了结果,但显示出患者反应的变化.
预测癌症缓解症中饮食变化的个体反应仍然具有挑战性.

研究的目的:

确定肠道微生物组特征作为预测性生物标志物,用于癌症缓解症的营养干预反应.
调查基线微生物组资料和体重变化之间的关联.
探索饮食干预后的微生物组变化.

主要方法:

从癌症缓解症诊所 (CNR-JGH) 招募的患者.
提供个性化的营养咨询,以增加能量和蛋白质摄入量.
在基线和干预后分析了便DNA,以检测肠道微生物群的特征 (多样性,品种丰富性).

主要成果:

较高的基线α-多样性和Lachnospira属的丰富性预测了积极的体重反应 (体重维持/增加).
减肥患者在干预后表现出较低的α多样性和增加的微生物不稳定性.
没有确定反应不良 (体重减轻) 的预测因素.

结论:

肠道微生物组的特征与食干预反应在癌症缓解症相关.
拉克诺斯皮拉的丰富性可以预测体重的积极变化,有助于多式联络护理.
保持肠道微生物群的多样性和稳定性可以提高营养干预的有效性.

关键词:

癌症缓冲症癌症缓冲症我们的肠道微生物组.多学科缓解症诊所缓解症诊所营养咨询营养咨询预测性的生物标志物体重变化体重变化

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