中度至严重的阻塞性睡眠呼吸暂停是严重COVID-19的危险因素-全国性队列研究
Mirjam Ljunggren1, Andreas Palm1, Magnus Ekström2
1Department of Medical Sciences, Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden.
Journal of sleep research
|May 6, 2025
概括
阻塞性睡眠呼吸暂停 (OSA) 增加了严重的COVID-19的风险,即使有正气道压力 (PAP) 治疗. 中度至重度的OSA显示了与COVID-19严重程度的剂量反应关系.
科学领域:
- 睡眠医学 睡眠医学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 是一种常见的疾病,影响着全球数以百万计的人.
- 在OSA,阳性气道压力 (PAP) 治疗和COVID-19严重程度之间的关系仍然不完全理解.
- 了解这些关联对于在COVID-19大流行期间管理OSA患者至关重要.
研究的目的:
- 为了确定OSA是否是严重COVID-19的独立风险因素.
- 调查PAP治疗坚持和临床特征对OSA患者COVID-19严重程度的影响.
- 评估OSA严重程度 (间歇性缺氧) 和COVID-19结果之间的剂量反应关系.
主要方法:
- 一项基于人口的全国性研究,利用瑞典多个注册表的数据.
- 包括2020年1月至2022年5月期间被诊断患有COVID-19的瑞典居民.
- 在使用多项逻辑回归调整共变量后,在患有OSA和没有OSA的个体之间比较COVID-19的严重程度 (轻度,严重,危急).
主要成果:
- OSA与严重 (COR 1.34) 和危急 (COR 1.25) COVID-19 的风险显著增加有关.
- 这种增加的风险在PPP附属和非附属个体以及40至60岁的人群中都被观察到.
- 在OSA严重程度 (氧气不和指数-ODI) 和COVID-19严重程度之间发现了明确的剂量反应关系,ODI≥30显示了最高的风险.
结论:
- 中度至重度的OSA是严重COVID-19的独立风险因素,无论PAP治疗如何.
- 在OSA患者中,间歇性缺氧的严重程度与COVID-19严重程度的增加直接相关.
- 这些发现强调了管理OSA以减轻COVID-19风险的重要性.
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