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长期的肺部后果 5-14 年后延长的细菌性支气管炎在幼儿时期
Jan Hermann1,2, Karen Brückner1,3, Cordula Koerner-Rettberg1,4
1Department of Paediatric Pneumology, University Children's Hospital, Ruhr-University, Bochum, Bochum, Germany.
Pediatric pulmonology
|May 6, 2025
概括
长期的细菌性支气管炎 (PBB) 在儿童时期可能导致长期的呼吸系统问题,包括持续的咳和减少的肺功能. 许多儿童经历了持续的症状和潜在的支气管壁变化几年后的初始感染.
科学领域:
- 儿科肺病学 儿科肺病学
- 呼吸系统医学 呼吸系统医学
- 儿童传染病 儿童传染病
背景情况:
- 长期细菌性支气管炎 (PBB) 是幼儿慢性湿咳的主要原因.
- 在PBB之后的长期肺部连续病例没有得到充分的证据.
- 了解这些长期影响对于有效的儿童呼吸系统健康管理至关重要.
研究的目的:
- 在PBB诊断几年后,对儿童的长期肺功能和呼吸系统症状进行调查.
- 为了确定与以前的PBB相关的潜在结构性肺部变化.
- 评估持续湿咳对长期呼吸系统结果的预测价值.
主要方法:
- 一组62名确诊PBB的儿童在平均7.7年后接受了后续采访和肺功能测试 (PFT).
- PFT包括螺旋测量,身体囊造影和清洗.
- 提供肺部成像 (MRI/CT) 的孩子有持续的症状.
主要成果:
- 17.7%的儿童在PBB后的几年里报告了慢性或反复出现的湿咳.
- 24.19%的人表现出异常的螺旋计结果,FEV1,FVC或FEV1/FVC比率降低.
- 支气管壁异常,包括早期支气管切除,在44%接受成像的人群中观察到.
结论:
- 在PBB发生多年后,有相当数量的儿童经历了持续的呼吸道症状和肺功能下降.
- 即使在初始PBB治疗后,也可能发生结构性支气管变化.
- 建议进行持续的随访,以监测和管理这些儿童晚期支气管肺部并发症.
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