[68Ga]Ga-DOTATATE PET/CT成像中的诊断陷:一个系统性审查
Ahmed Saad Abdlkadir1, Dhuha Al-Adhami1, Mohammed Al Rammahi1
1Department of Nuclear Medicine, King Hussein Cancer Center (KHCC), Amman, Jordan, .
本综述确定了用于神经内分泌瘤的-68Ga-DOTA-Tyr3-octreotate ([68Ga]Ga-DOTATATE) 成像的诊断陷. 了解这些陷是准确诊断和潜在的新用途的关键.
科学领域:
- 核医学就是核医学.
- 放射性药房 是一个放射性药房.
- 在瘤学瘤学.
背景情况:
- [68Ga]Ga-DOTATATE是神经内分泌瘤 (NETs) 和脑膜瘤的关键体静止素受体成像剂.
- 虽然有效,但[68Ga]Ga-DOTATATE成像具有诊断挑战,报告了错误的阳性结果.
- 需要进行系统审查,以巩固已知的诊断陷.
研究的目的:
- 系统地审查和识别[68Ga]Ga-DOTATATE正子成像中的诊断陷.
- 分析这些陷的特征和解剖分布.
- 为了提供准确的解释,并探索[68Ga]Ga-DOTATATE的扩展应用.
主要方法:
- 在PubMed,Scopus和Web of Science数据库中的系统文献搜索.
- 两个作者对选的标题和摘要应用的包含/排除标准.
- 对70篇精选文章 (199名患者) 的定性分析,以识别和分类诊断陷.
主要成果:
- 在70项研究中,共发现了234个诊断陷.
- 恶性瘤病因占患病的56%,其次是非瘤病因 (32.1%) 和良性瘤病因 (11.9%).
- 头部和部地区受影响最大 (35.5%),肌肉骨 (27.4%),腹部 (17.5%) 和胸部 (16.6%) 区域也出现了陷.
结论:
- [68Ga]Ga-DOTATATE成像的诊断陷是显著的,特别是在头部和部地区.
- 了解这些陷对于准确诊断NET和脑膜瘤至关重要.
- 识别陷可能会揭示[68Ga]Ga-DOTATATE的新应用,超出目前的用途.
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