使用拉曼光谱学的itopride固体剂型的定量分析
Iqra Naheed1, Maida Ehsan1, Haq Nawaz1
1Department of Chemistry, University of Agriculture Faisalabad, Faisalabad (38000), Pakistan.
Current pharmaceutical design
|May 6, 2025
概括
拉曼光谱学准确地量化了固体剂型中的伊托普里德. 主要成分分析 (PCA) 和部分最小平方回归分析 (PLS-RA) 允许可靠的识别和度的确定.
科学领域:
- 制药分析 制药分析
- 频谱学技术的使用
背景情况:
- 拉曼光谱为制药分析提供了一种非侵入性,快速和准确的方法.
- 它适用于复杂配方中的活性药物成分的识别和量化.
研究的目的:
- 探索拉曼光谱的应用,以识别和量化固体剂型中的伊托普里德.
- 评估用于制药分析的多变量数据分析技术的有效性.
主要方法:
- 在固体剂型中分析了伊托普里德的拉曼光谱特征.
- 主要组件分析 (PCA) 和部分最小平方回归分析 (PLS-RA) 被用作多变量数据分析技术.
主要成果:
- PCA有效地区分了各种itopride药物样本的拉曼光谱数据.
- PLS-RA实现了R2值为0.999%的定量分析,表明了出色的模型变异性解释.
- 该方法准确地确定了未知配方中的伊托普里德度,计算度为79.66/80毫克 (w/w).
结论:
- 拉曼光谱与PLS-RA相结合,可靠地确定制药样品中的伊托普里德度.
- 这种方法对于固体剂型的质量控制是有效的.
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