生物灵感的3D打印NIR响应的MXene型多功能Eutectogel微针用于个性化的受感染伤口愈合
Huan Liu1, Aminov Nail1, Decheng Meng1
1State Key Laboratory of Environment Characteristics and Effects for Near-space, Key Laboratory of Cluster Science of Ministry of Education, Key Laboratory of Medical Molecule Science and Pharmaceutics Engineering of Ministry of Industry and Information Technology, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing, 100081, China.
Advanced healthcare materials
|May 6, 2025
概括
灵感来自鱼牙的新型微针贴片有效地治愈受感染的伤口. 这种生物灵感的贴片使用MXene纳米片和一种特殊的凝,用于抗菌作用,组织修复和控制药物输送,显著改善伤口关闭.
科学领域:
- 生物材料科学 生物材料科学
- 再生医学是一种再生医学.
- 纳米技术纳米技术
背景情况:
- 受感染的伤口愈合带来了复杂的挑战,需要多方面的治疗方法.
- 目前的治疗方法往往缺乏同时对抗感染,促进组织再生和有效管理药物输送的能力.
研究的目的:
- 开发一种生物灵感,3D打印的微针贴片,用于先进的感染性伤口愈合.
- 整合MXene纳米片和一个可聚合的深层环氧溶剂,以增强治疗功能.
主要方法:
- 制造基于MXene的eutectogel微针 (MF-MXene@MN) 使用DPL3D打印与梯度高度设计.
- 纳入MXene纳米片和一个可聚合的深溶解溶剂 (PDES),包括乙烯酸 (VP),伊塔康酸 (IA) 和N-异烯酸胺 (NIPAM).
- 对光热反应,抗氧化活性和刺激触发的药物释放 (曼吉费林) 的评估.
主要成果:
- 显示明显的伤口关闭 (10天内94.88%) 和增强的血管生成 (增加3.2倍).
- 实现了实质性的细菌减少 (根据NIR,S. aureus和E. coli的总体生存能力减少了68%).
- 展示了通过NIR刺激对pH和温度变化做出反应的受控曼吉费林释放 (88.3%的累积释放).
结论:
- MF-MXene@MN平台为感染伤口管理提供了一个多功能解决方案.
- 生物灵感设计,刺激响应材料和3D打印使抗菌效率优越,组织再生和药物输送控制成为可能.
- 这种创新方法代表了精确伤口护理的重大进步.
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